Antioxidative catechol lignans converted from sesamin and sesaminol triglucoside by culturing with Aspergillus

Yoshiaki Miyake, Syuichi Fukumoto, Miki Okada, Kazuhiro Sakaida, Yoshimasa Nakamura, Toshihiko Osawa

Research output: Contribution to journalArticlepeer-review

82 Citations (Scopus)


Sesamin and sesaminol triglucoside in sesame seeds are major lignans that display an abundance of biological activities. Although their antioxidative activity in vitro is weak, they have been reported to suppress oxidative stress in vivo. We investigated the production of new antioxidative lignans from sesame lignans by culturing with the genus Aspergillus to enhance the function of food materials. Media containing sesamin or sesaminol triglucoside increased antioxidative activity for DPPH radical scavenging by culturing with Aspergillus usamii mut. shirousamii RIB2503. The antioxidative lignans in sesamin medium were identified as sesamin 2,6-dicatechol and episesamin 2,6-dicatechol. Those in sesaminol triglucoside medium were identified as sesaminol 6-catechol and episesaminol 6-catechol, which are novel antioxidative lignans. It is suggested that they may exhibit higher antioxidative activity than sesamin and sesaminol triglucoside because they have the catechol functional moiety.

Original languageEnglish
Pages (from-to)22-27
Number of pages6
JournalJournal of agricultural and food chemistry
Issue number1
Publication statusPublished - Jan 12 2005
Externally publishedYes


  • Antioxidant
  • Aspergillus
  • Catechol
  • Lignan
  • Sesame

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)


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