Antisense oligonucleotides

Naoki Kashihara, Yohei Maeshima, Hirofumi Makino

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Antisense technology was developed to inhibit gene expression by utilizing an oligonucleotide complementary to the mRNA which encodes the target gene. There are a few possible mechanisms for the inhibitory effects of antisense oligonucleotides. Among them, degradation of mRNA by RNase H is considered to be the major mechanism of action for antisense oligonucleotides. This technique was originally used to elucidate the function of a target gene, but may also have therapeutic applications, provided it is designed carefully and properly.

Original languageEnglish
Pages (from-to)84-88
Number of pages5
JournalExperimental Nephrology
Issue number1
Publication statusPublished - Mar 13 1998


  • Antisense oligonucleotides
  • Gene therapy
  • Liposomes

ASJC Scopus subject areas

  • Nephrology


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