Antitumor effect of interleukin-2 (IL-2) mini-pellet plus LAK cells on Meth-A sarcoma in mice

Toshiyoshi Fujiwara; Ken ichi Sakagami; Junji Matsuoka; Shigehiro Shiozaki; Susumu Uchida; Takenori Kawamura; Shinji Takasu; Futoshi Morisaki; Shinya Saito; Toshihiko Owa; Minoru Haisa; Masaru Inagaki; Kunzo Orita

doi:10.2745/dds.3.437

Antitumor effect of interleukin-2 (IL-2) mini-pellet plus LAK cells on Meth-A sarcoma in mice

Toshiyoshi Fujiwara, Ken ichi Sakagami, Junji Matsuoka, Shigehiro Shiozaki, Susumu Uchida, Takenori Kawamura, Shinji Takasu, Futoshi Morisaki, Shinya Saito, Toshihiko Owa, Minoru Haisa, Masaru Inagaki, Kunzo Orita

Research output: Contribution to journal › Article › peer-review

Abstract

We have evaluated the antitumor effect of IL-2 mini-pellet on the therapy of murine Meth-A sarcoma. After the administration of IL-2 mini-pellet containing 1×10⁶u of IL-2, the serum IL-2 activity was detectable for 72 hours. The s. c. administration of IL-2 mini-pellet and the i. v. injection of LAK cells was effective in inhibiting the tumor growth and could also prolong the survivals. The lytic activites of splenocytes against YAC-1 cells and JTC-11 cells after the administration of IL-2 mini-pellet were augmented. In histological examination on day 7 after the administration of IL-2 mini-pellet, a lot of lymphocytes were invased into tumor tissues. These results suggest that IL-2 mini-pellet can be applied to the adoptive immunotherapy using LAK cells.

Original language	English
Pages (from-to)	437-443
Number of pages	7
Journal	Drug Delivery System
Volume	3
Issue number	3
DOIs	https://doi.org/10.2745/dds.3.437
Publication status	Published - 1988

Keywords

LAK cells
Meth-A sarcoma
adoptive immunotherapy
interleukin-2

ASJC Scopus subject areas

Pharmaceutical Science

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10.2745/dds.3.437

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title = "Antitumor effect of interleukin-2 (IL-2) mini-pellet plus LAK cells on Meth-A sarcoma in mice",

abstract = "We have evaluated the antitumor effect of IL-2 mini-pellet on the therapy of murine Meth-A sarcoma. After the administration of IL-2 mini-pellet containing 1×106u of IL-2, the serum IL-2 activity was detectable for 72 hours. The s. c. administration of IL-2 mini-pellet and the i. v. injection of LAK cells was effective in inhibiting the tumor growth and could also prolong the survivals. The lytic activites of splenocytes against YAC-1 cells and JTC-11 cells after the administration of IL-2 mini-pellet were augmented. In histological examination on day 7 after the administration of IL-2 mini-pellet, a lot of lymphocytes were invased into tumor tissues. These results suggest that IL-2 mini-pellet can be applied to the adoptive immunotherapy using LAK cells.",

keywords = "LAK cells, Meth-A sarcoma, adoptive immunotherapy, interleukin-2",

author = "Toshiyoshi Fujiwara and Sakagami, {Ken ichi} and Junji Matsuoka and Shigehiro Shiozaki and Susumu Uchida and Takenori Kawamura and Shinji Takasu and Futoshi Morisaki and Shinya Saito and Toshihiko Owa and Minoru Haisa and Masaru Inagaki and Kunzo Orita",

year = "1988",

doi = "10.2745/dds.3.437",

language = "English",

volume = "3",

pages = "437--443",

journal = "Drug Delivery System",

issn = "0913-5006",

publisher = "Japan Society of Drug Delivery System",

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T1 - Antitumor effect of interleukin-2 (IL-2) mini-pellet plus LAK cells on Meth-A sarcoma in mice

AU - Fujiwara, Toshiyoshi

AU - Sakagami, Ken ichi

AU - Matsuoka, Junji

AU - Shiozaki, Shigehiro

AU - Uchida, Susumu

AU - Kawamura, Takenori

AU - Takasu, Shinji

AU - Morisaki, Futoshi

AU - Saito, Shinya

AU - Owa, Toshihiko

AU - Haisa, Minoru

AU - Inagaki, Masaru

AU - Orita, Kunzo

PY - 1988

Y1 - 1988

N2 - We have evaluated the antitumor effect of IL-2 mini-pellet on the therapy of murine Meth-A sarcoma. After the administration of IL-2 mini-pellet containing 1×106u of IL-2, the serum IL-2 activity was detectable for 72 hours. The s. c. administration of IL-2 mini-pellet and the i. v. injection of LAK cells was effective in inhibiting the tumor growth and could also prolong the survivals. The lytic activites of splenocytes against YAC-1 cells and JTC-11 cells after the administration of IL-2 mini-pellet were augmented. In histological examination on day 7 after the administration of IL-2 mini-pellet, a lot of lymphocytes were invased into tumor tissues. These results suggest that IL-2 mini-pellet can be applied to the adoptive immunotherapy using LAK cells.

AB - We have evaluated the antitumor effect of IL-2 mini-pellet on the therapy of murine Meth-A sarcoma. After the administration of IL-2 mini-pellet containing 1×106u of IL-2, the serum IL-2 activity was detectable for 72 hours. The s. c. administration of IL-2 mini-pellet and the i. v. injection of LAK cells was effective in inhibiting the tumor growth and could also prolong the survivals. The lytic activites of splenocytes against YAC-1 cells and JTC-11 cells after the administration of IL-2 mini-pellet were augmented. In histological examination on day 7 after the administration of IL-2 mini-pellet, a lot of lymphocytes were invased into tumor tissues. These results suggest that IL-2 mini-pellet can be applied to the adoptive immunotherapy using LAK cells.

KW - LAK cells

KW - Meth-A sarcoma

KW - adoptive immunotherapy

KW - interleukin-2

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DO - 10.2745/dds.3.437

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JO - Drug Delivery System

JF - Drug Delivery System

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Antitumor effect of interleukin-2 (IL-2) mini-pellet plus LAK cells on Meth-A sarcoma in mice

Abstract

Keywords

ASJC Scopus subject areas

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