Antitumorigenic and antipromoting activities of ellagic acid, ellagitannins and oligomeric anthocyanin and procyanidin

Andre Castonguay, Hala U. Gali, Elisabeth M. Perchellet, Xiao M. Gao, Mohamed Boukharta, Guylaine Jalbert, Takuo Okuda, Takashi Yoshida, Tsutomu Hatano, Jean Pierre Perchellet

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)


We previously showed that ellagic acid (EA) was inhibiting lung tumorigenesis induced by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone (NNK) in A/J mice. In the present study, we observed that the inhibition of lung tumorigenesis was independent of the solvent used to purified EA. Pomegranate peels extract containing punicalagin (α and β anomers) (10 g/kg diet) and oligomeric anthocyanins (6 g/kg diet) did not inhibit lung tumorigenesis. Raspberry extract (2 x 15 mg) containing sanguiin H6 and lambertianin D as well as oligomeric procyanidins (2 x 15 mg) inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity by about 30%. The same treatments inhibit TPA-stimulated hydroperoxide (HPx) production by about 30 and 70%. Raspberry ellagitannins and oligomeric procyanidins respectively inhibit TPA stimulated DNA synthesis by 42 and 26%. Our results suggest that hydrolyzable and condensed tannins from various sources, which can inhibit the ODC, HPx, and DNA responses to TPA, might also inhibit the tumor-promoting activity of this agent. The results of this study show that EA and ellagitannins have different antitumorigenic and antipromoting activities.

Original languageEnglish
Pages (from-to)367-373
Number of pages7
JournalInternational journal of oncology
Issue number2
Publication statusPublished - Feb 1997


  • anthocyanin
  • ellagic acid
  • ellagitannins
  • procyanidin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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