Antitumour activities of sesquiterpene lactones from Inula helenium and Inula japonica

Yong Li, Zhi Yu Ni, Meng Chu Zhu, Mei Dong, Si Ming Wang, Qing Wen Shi, Man Li Zhang, Yu Fang Wang, Chang Hong Huo, Hiromasa Kiyota, Bin Cong

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Eight sesquiterpene lactones were isolated from the roots of Inula helenium and flowers of I. japonica. Among them, isoalantolactone (3) and santamarine (6) exhibited significant growth inhibitory activities against gynecologic cancer cell lines, while others weakly inhibited the growth of the cell lines (IC50 ≤ 100 μM). In addition, 3 significantly inhibited the tumour growth of S180 tumour-bearing mice. Compounds 3 and 6 were not toxic to human embryonic lung fibroblast cells in vitro. These results demonstrated that the antitumour activities are closely related to the structures of the compounds, that is, an α-exomethylene-γ-lactone ring is necessary for these activities.

Original languageEnglish
Pages (from-to)375-380
Number of pages6
JournalZeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume67 C
Issue number7-8
Publication statusPublished - 2012
Externally publishedYes


  • Antitumour activity
  • Inula sp.
  • Sesquiterpenes

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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