Artificial food colorants inhibit superoxide production in differentiated HL-60 Cells

Hang Qi; Machiko Kawagishi; Motoko Yoshimoto; Hiroshi Takano; Beiwei Zhu; Yasuaki Shimoishi; Mikiro Tada; Yoshiyuki Murata; Yoshimasa Nakamura

doi:10.1271/bbb.100314

Artificial food colorants inhibit superoxide production in differentiated HL-60 Cells

Hang Qi, Machiko Kawagishi, Motoko Yoshimoto, Hiroshi Takano, Beiwei Zhu, Yasuaki Shimoishi, Mikiro Tada, Yoshiyuki Murata, Yoshimasa Nakamura

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We tested synthetic food colorants for their antioxidative potential by the in vitro superoxide generation assay in differentiated HL-60 cells in response tophorbol ester. Among the 12 colorants tested, such fluorescein-type red colorants as rose bengal showed potent inhibitory activity without any cytotoxicity under dark conditions. The intracellular accumulation and superoxide anion scavenging effect of rose bengal were at least partly involved in the inhibitory activity.

Original language	English
Pages (from-to)	1725-1728
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	74
Issue number	8
DOIs	https://doi.org/10.1271/bbb.100314
Publication status	Published - 2010

Keywords

Food colorant
HL-60 cell
Rose bengal
Superoxide
Xanthine oxidase

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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10.1271/bbb.100314

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title = "Artificial food colorants inhibit superoxide production in differentiated HL-60 Cells",

abstract = "We tested synthetic food colorants for their antioxidative potential by the in vitro superoxide generation assay in differentiated HL-60 cells in response tophorbol ester. Among the 12 colorants tested, such fluorescein-type red colorants as rose bengal showed potent inhibitory activity without any cytotoxicity under dark conditions. The intracellular accumulation and superoxide anion scavenging effect of rose bengal were at least partly involved in the inhibitory activity.",

keywords = "Food colorant, HL-60 cell, Rose bengal, Superoxide, Xanthine oxidase",

author = "Hang Qi and Machiko Kawagishi and Motoko Yoshimoto and Hiroshi Takano and Beiwei Zhu and Yasuaki Shimoishi and Mikiro Tada and Yoshiyuki Murata and Yoshimasa Nakamura",

note = "Funding Information: This work was supported in part by The Japan Food Chemical Research Foundation.",

year = "2010",

doi = "10.1271/bbb.100314",

language = "English",

volume = "74",

pages = "1725--1728",

journal = "Bioscience, Biotechnology and Biochemistry",

issn = "0916-8451",

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TY - JOUR

T1 - Artificial food colorants inhibit superoxide production in differentiated HL-60 Cells

AU - Qi, Hang

AU - Kawagishi, Machiko

AU - Yoshimoto, Motoko

AU - Takano, Hiroshi

AU - Zhu, Beiwei

AU - Shimoishi, Yasuaki

AU - Tada, Mikiro

AU - Murata, Yoshiyuki

AU - Nakamura, Yoshimasa

N1 - Funding Information: This work was supported in part by The Japan Food Chemical Research Foundation.

PY - 2010

Y1 - 2010

N2 - We tested synthetic food colorants for their antioxidative potential by the in vitro superoxide generation assay in differentiated HL-60 cells in response tophorbol ester. Among the 12 colorants tested, such fluorescein-type red colorants as rose bengal showed potent inhibitory activity without any cytotoxicity under dark conditions. The intracellular accumulation and superoxide anion scavenging effect of rose bengal were at least partly involved in the inhibitory activity.

AB - We tested synthetic food colorants for their antioxidative potential by the in vitro superoxide generation assay in differentiated HL-60 cells in response tophorbol ester. Among the 12 colorants tested, such fluorescein-type red colorants as rose bengal showed potent inhibitory activity without any cytotoxicity under dark conditions. The intracellular accumulation and superoxide anion scavenging effect of rose bengal were at least partly involved in the inhibitory activity.

KW - Food colorant

KW - HL-60 cell

KW - Rose bengal

KW - Superoxide

KW - Xanthine oxidase

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DO - 10.1271/bbb.100314

M3 - Article

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AN - SCOPUS:77956027606

SN - 0916-8451

VL - 74

SP - 1725

EP - 1728

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 8

ER -

Artificial food colorants inhibit superoxide production in differentiated HL-60 Cells

Abstract

Keywords

ASJC Scopus subject areas

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