Artificially produced meteorological changes aggravate pain in adjuvant-induced arthritic rats

Jun Sato; Morihiko Aoyama; Masahiro Yamazaki; Satoshi Okumura; Ken Takahashi; Megumi Funakubo; Kazue Mizumura

doi:10.1016/j.neulet.2003.09.057

Artificially produced meteorological changes aggravate pain in adjuvant-induced arthritic rats

Jun Sato, Morihiko Aoyama, Masahiro Yamazaki, Satoshi Okumura, Ken Takahashi, Megumi Funakubo, Kazue Mizumura

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

To examine the effects of change in meteorological parameters on pain-related behaviors in a simulated arthritic condition, rats with an injection of complete Freund's adjuvant into the tibio-tarsal joint were exposed to low barometric pressure (20 mmHg below the natural atmospheric pressure) and low ambient temperature (7°C lower than 22°C) in a climate-controlled room. When the arthritic rats were exposed to these environments, the already increased number of hindpaw withdrawals in response to noxious mechanical stimulation (hyperalgesia) was further increased, and a hindpaw withdrawal response to innocuous mechanical stimulation (allodynia) began to occur. Such exposures did not influence any of the pain-related behaviors of the control rats. These results show that lowering barometric pressure and ambient temperature within the range of natural environmental fluctuation intensify pain in arthritic rats.

Original language	English
Pages (from-to)	46-49
Number of pages	4
Journal	Neuroscience Letters
Volume	354
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2003.09.057
Publication status	Published - Jan 2 2004
Externally published	Yes

Keywords

Mechanical allodynia
Mechanical hyperalgesia
Monoarthritis
Rat
Rheumatic pain
Weather

ASJC Scopus subject areas

Neuroscience(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.neulet.2003.09.057

Cite this

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title = "Artificially produced meteorological changes aggravate pain in adjuvant-induced arthritic rats",

abstract = "To examine the effects of change in meteorological parameters on pain-related behaviors in a simulated arthritic condition, rats with an injection of complete Freund's adjuvant into the tibio-tarsal joint were exposed to low barometric pressure (20 mmHg below the natural atmospheric pressure) and low ambient temperature (7°C lower than 22°C) in a climate-controlled room. When the arthritic rats were exposed to these environments, the already increased number of hindpaw withdrawals in response to noxious mechanical stimulation (hyperalgesia) was further increased, and a hindpaw withdrawal response to innocuous mechanical stimulation (allodynia) began to occur. Such exposures did not influence any of the pain-related behaviors of the control rats. These results show that lowering barometric pressure and ambient temperature within the range of natural environmental fluctuation intensify pain in arthritic rats.",

keywords = "Mechanical allodynia, Mechanical hyperalgesia, Monoarthritis, Rat, Rheumatic pain, Weather",

author = "Jun Sato and Morihiko Aoyama and Masahiro Yamazaki and Satoshi Okumura and Ken Takahashi and Megumi Funakubo and Kazue Mizumura",

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AU - Sato, Jun

AU - Aoyama, Morihiko

AU - Yamazaki, Masahiro

AU - Okumura, Satoshi

AU - Takahashi, Ken

AU - Funakubo, Megumi

AU - Mizumura, Kazue

PY - 2004/1/2

Y1 - 2004/1/2

N2 - To examine the effects of change in meteorological parameters on pain-related behaviors in a simulated arthritic condition, rats with an injection of complete Freund's adjuvant into the tibio-tarsal joint were exposed to low barometric pressure (20 mmHg below the natural atmospheric pressure) and low ambient temperature (7°C lower than 22°C) in a climate-controlled room. When the arthritic rats were exposed to these environments, the already increased number of hindpaw withdrawals in response to noxious mechanical stimulation (hyperalgesia) was further increased, and a hindpaw withdrawal response to innocuous mechanical stimulation (allodynia) began to occur. Such exposures did not influence any of the pain-related behaviors of the control rats. These results show that lowering barometric pressure and ambient temperature within the range of natural environmental fluctuation intensify pain in arthritic rats.

AB - To examine the effects of change in meteorological parameters on pain-related behaviors in a simulated arthritic condition, rats with an injection of complete Freund's adjuvant into the tibio-tarsal joint were exposed to low barometric pressure (20 mmHg below the natural atmospheric pressure) and low ambient temperature (7°C lower than 22°C) in a climate-controlled room. When the arthritic rats were exposed to these environments, the already increased number of hindpaw withdrawals in response to noxious mechanical stimulation (hyperalgesia) was further increased, and a hindpaw withdrawal response to innocuous mechanical stimulation (allodynia) began to occur. Such exposures did not influence any of the pain-related behaviors of the control rats. These results show that lowering barometric pressure and ambient temperature within the range of natural environmental fluctuation intensify pain in arthritic rats.

KW - Mechanical allodynia

KW - Mechanical hyperalgesia

KW - Monoarthritis

KW - Rat

KW - Rheumatic pain

KW - Weather

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Artificially produced meteorological changes aggravate pain in adjuvant-induced arthritic rats

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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