Aryl-aryl coupling reaction using a novel and highly active palladium reagent prepared from Pd(OAc)2, 1,3-Bis[diphenylphosphino]propane (DPPP), and Bu3P

Takashi Harayama; Toshihiko Akiyama; Yuichiro Nakano; Hiromi Nishioka; Hitoshi Abe; Yasuo Takeuchi

doi:10.1248/cpb.50.519

Aryl-aryl coupling reaction using a novel and highly active palladium reagent prepared from Pd(OAc)₂, 1,3-Bis[diphenylphosphino]propane (DPPP), and Bu₃P

Takashi Harayama, Toshihiko Akiyama, Yuichiro Nakano, Hiromi Nishioka, Hitoshi Abe, Yasuo Takeuchi

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

A palladium-assisted coupling reaction of aryl triflate with arene was investigated, and a novel Pd reagent prepared from equimolar Pd(OAc) ₂, 1,3-Bis[diphenylphosphino]propane (DPPP), and Bu₃P was developed. This method is useful for intramolecular biaryl coupling reactions, not only between aryl triflate and arene (triflate-amide), but also between aryl halide and arene (halo-amide).

Original language	English
Pages (from-to)	519-522
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	50
Issue number	4
DOIs	https://doi.org/10.1248/cpb.50.519
Publication status	Published - Apr 2002

Keywords

Aryl halide-arene coupling
Aryl triflate-arene coupling
Biaryl coupling
Bidentate ligand
Palladium

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

Access to Document

10.1248/cpb.50.519

Cite this

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title = "Aryl-aryl coupling reaction using a novel and highly active palladium reagent prepared from Pd(OAc)2, 1,3-Bis[diphenylphosphino]propane (DPPP), and Bu3P",

abstract = "A palladium-assisted coupling reaction of aryl triflate with arene was investigated, and a novel Pd reagent prepared from equimolar Pd(OAc) 2, 1,3-Bis[diphenylphosphino]propane (DPPP), and Bu3P was developed. This method is useful for intramolecular biaryl coupling reactions, not only between aryl triflate and arene (triflate-amide), but also between aryl halide and arene (halo-amide).",

keywords = "Aryl halide-arene coupling, Aryl triflate-arene coupling, Biaryl coupling, Bidentate ligand, Palladium",

author = "Takashi Harayama and Toshihiko Akiyama and Yuichiro Nakano and Hiromi Nishioka and Hitoshi Abe and Yasuo Takeuchi",

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T1 - Aryl-aryl coupling reaction using a novel and highly active palladium reagent prepared from Pd(OAc)2, 1,3-Bis[diphenylphosphino]propane (DPPP), and Bu3P

AU - Harayama, Takashi

AU - Akiyama, Toshihiko

AU - Nakano, Yuichiro

AU - Nishioka, Hiromi

AU - Abe, Hitoshi

AU - Takeuchi, Yasuo

PY - 2002/4

Y1 - 2002/4

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AB - A palladium-assisted coupling reaction of aryl triflate with arene was investigated, and a novel Pd reagent prepared from equimolar Pd(OAc) 2, 1,3-Bis[diphenylphosphino]propane (DPPP), and Bu3P was developed. This method is useful for intramolecular biaryl coupling reactions, not only between aryl triflate and arene (triflate-amide), but also between aryl halide and arene (halo-amide).

KW - Aryl halide-arene coupling

KW - Aryl triflate-arene coupling

KW - Biaryl coupling

KW - Bidentate ligand

KW - Palladium

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