Assessment of human erythrocyte deformability during gestation by electron spin resonance

K. Eguchi, Y. Mitsui, Y. Hiramatsu, S. Noji

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


To investigate hemorheological alterations during pregnancy, erythrocyte deformability was measured by the electron spin resonance (ESR) method in 10 women with uncomplicated pregnancy, 7 pre-eclamptic patients, and 10 non-pregnant controls. Erythrocyte deformability decreased significantly during pregnancy, and recovered to the non-pregnant control level on puerperal day 7. Deformability was significantly lower in the pre-eclampsia group than in the normal pregnancy group. In addition, erythrocyte deformability increased significantly when isoxsuprine or α-tocopherol were added to red cells suspensions of either the normal pregnancy or pre-eclampsia group. These data suggest the possibility of administration of isoxsuprine or α-tocopherol to increase erythrocyte deformability and improve placental perfusion.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalInternational Journal of Feto-Maternal Medicine
Issue number3
Publication statusPublished - Dec 1 1992


  • erythrocyte deformability
  • isoxsuprine
  • pre-eclampsia
  • α-tocopherol

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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