Association between histological types and enhancement of dynamic ct for primary lung cancer

Shogo Fukuma, Takayoshi Shinya, Junichi Sou, Ryuichiro Fukuhara, Nanako Ogawa, Fumiyo Higaki, Takehiro Tanaka, Eiki Ichihara, Takao Hiraki, Shinichi Toyooka, Susumu Kanazawa

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The aim of this study was to explore enhancement patterns of different types of primary lung cancers on 2-phase dynamic computed tomography (CT). This study included 217 primary lung cancer patients (141 adenocarcinomas [ADs], 48 squamous cell carcinomas [SCCs], 20 small cell lung carcinomas [SCLCs], and 8 others) who were examined using a 2-phase dynamic scan. Regions of interest were identified and mean enhancement values were calculated. After excluding the 20 SCLCs because these lesions had different clinical stages from the other cancer types, the mean attenuation values and subtractions between phases were compared between types of non-small cell lung carcinomas (NSCLCs) using the Kruskal-Wallis test. Late phase attenuation and attenuation of the late minus unenhanced phase (LMU) of SCCs were significantly higher than those of ADs (p<0.05). To differentiate SCC and AD in the late phase, a threshold of 80.21 Hounsfield units (HU) gave 52.9% accuracy. In LMU, a threshold of 52.16 HU gave 59.3% accuracy. Dynamic lung CT has the potential to aid in differentiating among NSCLC types.

Original languageEnglish
Pages (from-to)129-135
Number of pages7
JournalActa medica Okayama
Issue number2
Publication statusPublished - 2020


  • Differentiation
  • Dynamic computed tomography
  • Enhancement pattern
  • Primary lung cancer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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