Association between mammographic breast density and lifestyle in japanese women

Setsuko Ishihara, Naruto Taira, Kensuke Kawasakic, Youichi Ishibe, Taeko Mizoo, Keiko Nishiyama, Takayuki Iwamoto, Tomohiro Nogami, Takayuki Motoki, Tadahiko Shieir, Junji Matsuoka, Hiroyoshi Doihara, Yoshifumi Komoike, Shuhei Sato, Susumu Kanazawa

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


A high mammographic breast density is considered to be a risk factor for breast cancer. However, only a small number of studies on the association between breast density and lifestyle have been per- formed. A cross-sectional study was performed using a survey with 29 questions on life history and lifestyle. The breast density on mammography was classified into 4 categories following the BI-RADS criteria. The subjects were 522 women with no medical history of breast cancer. The mean age was 53.3 years old. On multivariate analysis, only BMI was a significant factor determining breast density in premenopausal women (parameter estimate, 0.403; p value, 0.0005), and the density decreased as BMI rose. In postmenopausal women, BMI (parameter estimate, 0.196; p value, 0.0143) and number of deliveries (parameter estimate, 0.388; p value, 0.0186) were significant factors determining breast density; breast density decreased as BMI and number of deliveries increased. Only BMI and number of deliveries were identified as factors significantly influencing breast density. BMI was inversely cor- related with breast density before and after menopause, whereas the influence of number of deliveries on breast density was significant only in postmenopausal women in their 50 and 60s.

Original languageEnglish
Pages (from-to)145-151
Number of pages7
JournalActa medica Okayama
Issue number3
Publication statusPublished - 2013


  • Body mass index
  • Breast cancer
  • Life style
  • Mammographic breast density

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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