Association between serum γ-glutamyltransferase and oxidative stress related factors

Tomoko Takigawa, Yuri Hibino, Shingo Kimura, Hiroshi Yamauchi, Bingling Wang, Dahong Wang, Keiki Ogino

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Background/Aims: To investigate the main factors correlated with the serum γ-glutamyltransferase activity. Methodology: We measured serum γ-glutamyltransferase activity in 248 healthy Japanese people and determined its correlations with serum antioxidants, other plasma or serum factors, urinary 8-hydroxydeoxyguanine, and lifestyle factors. Results: The mean serum γ-glutamyltransferase activity was 29 IU/L. γ- Glutamyltransferase activities of males and persons older than 45 years were significantly higher than each counterpart. γ-Glutamyltransferase levels increased significantly with the number of cigarettes smoked per day and the frequency of alcohol consumption except for the persons who did not take alcohol. Additionally, γ-glutamyltransferase significantly correlated with urinary 8-hydroxydeoxyguanine, and with more blood factors including serum tocopherols, carotenoids, antioxidative enzymes, lipid peroxide, and free fatty acids than urinary 8-hydroxydeoxyguanine did. In multiple regression analyses, γ-glutamyltransferase had significant associations with retinol, 8-hydroxydeoxyguanine, docosahexaenoic acid, and cigarette smoking. Conclusions: Our present findings support the hypothesis that γ-glutamyltransferase can be used as a marker related with oxidative stress.

Original languageEnglish
Pages (from-to)50-53
Number of pages4
Issue number81
Publication statusPublished - Jan 2008
Externally publishedYes


  • Antioxidants
  • Biomarker
  • Cross-sectional study
  • Lifestyle factors
  • Retinol

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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