Association of adverse drug events with broad-spectrum antibiotic use in hospitalized patients: A single-center study

Hideharu Hagiya, Ryohei Kokado, Akiko Ueda, Hideo Okuno, Daiichi Morii, Shigeto Hamaguchi, Norihisa Yamamoto, Hisao Yoshida, Kazunori Tomono

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Objective The importance of antimicrobial stewardship is increasingly highlighted in this age of antimicrobial resistance. A better comprehension of adverse drug events (ADEs) can promote the appropriate use of antibiotics. We aimed to quantify the incidence of ADEs associated with broad-spectrum systemic antibiotics in a hospital setting. Methods We conducted a six-month prospective, observational study at Osaka University Hospital to describe the incidence of ADEs in patients hospitalized in general wards undergoing treatment with broadspectrum antibiotics [carbapenems, piperacillin/tazobactam (PIPC/TAZ), and anti-methicillin-resistant Staphylococcus aureus agents]. The occurrence of ADE was defined as any cardiac, gastrointestinal, hepatobiliary, renal, neurologic, hematologic, dermatologic, or musculoskeletal manifestation after 48 hours or more of systemic antibiotic therapy. Results The 3 most frequently prescribed antibiotics were PIPC/TAZ (242 cases), meropenem (181 cases), and vancomycin (92 cases). Of 689 patients, 118 (17.1%) experienced ADEs, including gastrointestinal (6.4%), hepatobiliary (4.2%), dermatologic (2.5%), and renal (2.3%) manifestations. Patients treated with PIPC/TAZ, meropenem, doripenem, vancomycin, daptomycin, and teicoplanin developed ADEs at rates of 20.7%, 16.0%, 15.4%, 19.6%, 11.8%, and 10.9%, respectively. Conclusion Our study provides a quantitative value for the incidence of ADEs associated with broadspectrum antibiotics in clinical practice. To optimize patient safety, clinicians need to be aware of the risks associated with antibiotic administration.

Original languageEnglish
Pages (from-to)2621-2625
Number of pages5
JournalInternal Medicine
Issue number18
Publication statusPublished - 2019
Externally publishedYes


  • Adverse drug event
  • Antibiotic stewardship
  • Antimicrobial resistance
  • Choosing wisely

ASJC Scopus subject areas

  • Internal Medicine


Dive into the research topics of 'Association of adverse drug events with broad-spectrum antibiotic use in hospitalized patients: A single-center study'. Together they form a unique fingerprint.

Cite this