TY - JOUR
T1 - Association of serum arginase i with oxidative stress in a healthy population
AU - Ogino, Keiki
AU - Takahashi, Noriko
AU - Takigawa, Tomoko
AU - Obase, Yasushi
AU - Wang, Da Hong
N1 - Funding Information:
This work was supported in part by Grant-in-Aid for Science Research No. 19390163 from the Ministry of Education, Culture, Sports, Science and Technology of the Japanese Government.
PY - 2011/2
Y1 - 2011/2
N2 - The association of serum arginase I with oxidative stress was evaluated cross-sectionally in a healthy population. The mean levels of serum arginase I in healthy people (n 278) were 32.6 ± 22.3 ng/ml. Significant correlations of arginase I were observed with age, WBC, RBC, alanine aminotransferase (ALT), high-sensitivity C-reactive protein (hs-CRP), uric acid, body mass index (BMI) and urinary 8-isoprostane. Multiple regression analysis showed significant associations of arginase I with WBC, RBC, urinary 8-hydroxydeoxyguanosine (8-OHdG), age, HbA1c and urinary 8-isoprostane. In the associations of arginase I with 8-OHdG, 8-isoprostane and HbA1c, confounding factors and lifestyle factors such as sex, old age, smoking and alcohol consumption were involved. It was concluded that serum arginase I was associated with oxidative stress and HbA1c in addition to age, WBC and RBC in healthy Japanese people and may become a new biomarker for early prediction of diabetes mellitus and other oxidative stress-related diseases
AB - The association of serum arginase I with oxidative stress was evaluated cross-sectionally in a healthy population. The mean levels of serum arginase I in healthy people (n 278) were 32.6 ± 22.3 ng/ml. Significant correlations of arginase I were observed with age, WBC, RBC, alanine aminotransferase (ALT), high-sensitivity C-reactive protein (hs-CRP), uric acid, body mass index (BMI) and urinary 8-isoprostane. Multiple regression analysis showed significant associations of arginase I with WBC, RBC, urinary 8-hydroxydeoxyguanosine (8-OHdG), age, HbA1c and urinary 8-isoprostane. In the associations of arginase I with 8-OHdG, 8-isoprostane and HbA1c, confounding factors and lifestyle factors such as sex, old age, smoking and alcohol consumption were involved. It was concluded that serum arginase I was associated with oxidative stress and HbA1c in addition to age, WBC and RBC in healthy Japanese people and may become a new biomarker for early prediction of diabetes mellitus and other oxidative stress-related diseases
KW - Arginase I
KW - Healthy people
KW - Oxidative stress
KW - Population study
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U2 - 10.3109/10715762.2010.520318
DO - 10.3109/10715762.2010.520318
M3 - Article
C2 - 20942574
AN - SCOPUS:78651275675
SN - 1071-5762
VL - 45
SP - 147
EP - 155
JO - Free Radical Research
JF - Free Radical Research
IS - 2
ER -
