Association of statins use and mortality outcomes in prostate cancer patients who received androgen deprivation therapy: a systematic review and meta-analysis

Abdulmajeed Aydh, Reza Sari Motlagh, Mishari Alshyarba, Keiichiro Mori, Satoshi Katayama, Nico Grossmann, Pawel Rajwa, Hadi Mostafai, Ekaterina Laukhtina, Benjamin Pradere, Fahad Quhal, Frederik König, Peter Nyirady, Pierre I. Karakiewicz, Martin Haydter, Shahrokh F. Shariat

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

Introduction While several recent studies investigated the influence of statins on survival outcomes in prostate cancer (PCa) patients on androgen deprivation therapy (ADT), definitive conclusions are still missing. The present systematic review and meta-analysis aimed to develop an overarching framework for the association of statins use and survival outcomes in PCa patients who receive ADT. Material and methods We conducted a systematic review and meta-analysis of the literature assessing the survival outcomes for statin compared to non-statin users in PCa patients who received ADT. We searched PubMed and Web of Science for studies published before March 1, 2021. We used the random effect model in the presence of heterogeneity and the fixed-effects model in the absence of heterogeneity per the I2 statistic. We did two meta-analyses; the primary meta-analysis was accomplished for articles reporting cancer-specific survival (CSS) as an outcome. A secondary meta-analysis was completed for articles reporting overall survival (OS) as an outcome. Results Ten studies were eligible for inclusion. Nine studies included in the first meta-analysis comprising 136,285 patients showed no statistically significant difference in CSS (HR 0.77; 95% CI 0.49–1.21) between statin users and non-users in PCa patients who received ADT. In four studies included in the second meta-analysis comprising 95,032 patients, statin users had a significantly better OS compared to non-users (HR 0.67; 95% CI 0.62–0.73). Conclusions Although the combination of statins and ADT in PCa patients significantly improves OS, it seems not to be through an effect on cancer-specific factors.

Original languageEnglish
Pages (from-to)484-490
Number of pages7
JournalCentral European Journal of Urology
Volume74
Issue number4
DOIs
Publication statusPublished - 2021

Keywords

  • learning curve in robotic surgery
  • nephron-sparing surgery
  • robot-assisted partial nephrectomy
  • robot-assisted partial nephrectomy
  • training in robotic surgery
  • vascular clamping

ASJC Scopus subject areas

  • Urology

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