Asymmetric inheritance of radial glial fibers by cortical neurons

Takaki Miyata, Ayano Kawaguchi, Hideyuki Okano, Masaharu Ogawa

Research output: Contribution to journalArticlepeer-review

418 Citations (Scopus)


Recent studies demonstrated the neuronogenic role of radial glial cells (RGCs) in the rodent. To reveal the fate of radial glial processes, we intensively monitored divisions of RGCs in DiI-labeled slices from the embryonic day 14 mouse cortex. During RGC division, each pia-connected fiber becomes thin but is neither lost nor divided; it is inherited asymmetrically by one daughter cell. In divisions that produce a neuron and a progenitor, the neuron inherits the pial fiber, also grows a thick ventricular process for several hours, and is therefore indistinguishable from the progenitor RGC. The ventricular process in the radial glial-like neuron ("radial neuron") then collapses, leading to ascent of the neuron by using the "recycled" radial fiber.

Original languageEnglish
Pages (from-to)727-741
Number of pages15
Issue number5
Publication statusPublished - Sept 13 2001
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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