Asymmetric synthesis of (+)-febrifugine and (+)-isofebrifugine using yeast reduction

Yasuo Takeuchi; Kumiko Azuma; Kentaro Takakura; Hitoshi Abe; Hye Sook Kim; Yusuke Wataya; Takashi Harayama

doi:10.1016/S0040-4020(00)01109-1

Asymmetric synthesis of (+)-febrifugine and (+)-isofebrifugine using yeast reduction

Yasuo Takeuchi, Kumiko Azuma, Kentaro Takakura, Hitoshi Abe, Hye Sook Kim, Yusuke Wataya, Takashi Harayama

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

The antimalarial agents febrifugine (D-1) and isofebrifugine (D-2) were synthesized from chiral 3-piperidinol (D-4), which was asymmetrically prepared by the yeast reduction of 3-piperidone derivatives (DL-3), with dynamic optical resolution.

Original language	English
Pages (from-to)	1213-1218
Number of pages	6
Journal	Tetrahedron
Volume	57
Issue number	7
DOIs	https://doi.org/10.1016/S0040-4020(00)01109-1
Publication status	Published - Feb 11 2001

Keywords

Antimalarial compounds
Asymmetric synthesis
Optical resolution
Reduction

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4020(00)01109-1

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title = "Asymmetric synthesis of (+)-febrifugine and (+)-isofebrifugine using yeast reduction",

abstract = "The antimalarial agents febrifugine (D-1) and isofebrifugine (D-2) were synthesized from chiral 3-piperidinol (D-4), which was asymmetrically prepared by the yeast reduction of 3-piperidone derivatives (DL-3), with dynamic optical resolution.",

keywords = "Antimalarial compounds, Asymmetric synthesis, Optical resolution, Reduction",

author = "Yasuo Takeuchi and Kumiko Azuma and Kentaro Takakura and Hitoshi Abe and Kim, {Hye Sook} and Yusuke Wataya and Takashi Harayama",

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doi = "10.1016/S0040-4020(00)01109-1",

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T1 - Asymmetric synthesis of (+)-febrifugine and (+)-isofebrifugine using yeast reduction

AU - Takeuchi, Yasuo

AU - Azuma, Kumiko

AU - Takakura, Kentaro

AU - Abe, Hitoshi

AU - Kim, Hye Sook

AU - Wataya, Yusuke

AU - Harayama, Takashi

PY - 2001/2/11

Y1 - 2001/2/11

N2 - The antimalarial agents febrifugine (D-1) and isofebrifugine (D-2) were synthesized from chiral 3-piperidinol (D-4), which was asymmetrically prepared by the yeast reduction of 3-piperidone derivatives (DL-3), with dynamic optical resolution.

AB - The antimalarial agents febrifugine (D-1) and isofebrifugine (D-2) were synthesized from chiral 3-piperidinol (D-4), which was asymmetrically prepared by the yeast reduction of 3-piperidone derivatives (DL-3), with dynamic optical resolution.

KW - Antimalarial compounds

KW - Asymmetric synthesis

KW - Optical resolution

KW - Reduction

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U2 - 10.1016/S0040-4020(00)01109-1

DO - 10.1016/S0040-4020(00)01109-1

M3 - Article

AN - SCOPUS:0035843361

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VL - 57

SP - 1213

EP - 1218

JO - Tetrahedron

JF - Tetrahedron

IS - 7

ER -

Asymmetric synthesis of (+)-febrifugine and (+)-isofebrifugine using yeast reduction

Abstract

Keywords

ASJC Scopus subject areas

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