Asymmetric synthesis of febrifugine and isofebrifugine using yeast reduction

Y. Takeuchi; K. Azuma; K. Takakura; H. Abe; T. Harayama

doi:10.1039/b005028h

Asymmetric synthesis of febrifugine and isofebrifugine using yeast reduction

Y. Takeuchi, K. Azuma, K. Takakura, H. Abe, T. Harayama

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

The antimalarial agents febrifugine ((+)-1) and isofebrifugine ((+)-2) were asymmetrically synthesized from chiral piperidin-3-ol ((+)-4), which was prepared by the reductive dynamic optical resolution of the 3-piperidone derivatives ((±)-3) using baker's yeast.

Original language	English
Pages (from-to)	1643-1644
Number of pages	2
Journal	Chemical Communications
Issue number	17
DOIs	https://doi.org/10.1039/b005028h
Publication status	Published - Sept 7 2000

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/b005028h

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title = "Asymmetric synthesis of febrifugine and isofebrifugine using yeast reduction",

abstract = "The antimalarial agents febrifugine ((+)-1) and isofebrifugine ((+)-2) were asymmetrically synthesized from chiral piperidin-3-ol ((+)-4), which was prepared by the reductive dynamic optical resolution of the 3-piperidone derivatives ((±)-3) using baker's yeast.",

author = "Y. Takeuchi and K. Azuma and K. Takakura and H. Abe and T. Harayama",

year = "2000",

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AU - Azuma, K.

AU - Takakura, K.

AU - Abe, H.

AU - Harayama, T.

PY - 2000/9/7

Y1 - 2000/9/7

N2 - The antimalarial agents febrifugine ((+)-1) and isofebrifugine ((+)-2) were asymmetrically synthesized from chiral piperidin-3-ol ((+)-4), which was prepared by the reductive dynamic optical resolution of the 3-piperidone derivatives ((±)-3) using baker's yeast.

AB - The antimalarial agents febrifugine ((+)-1) and isofebrifugine ((+)-2) were asymmetrically synthesized from chiral piperidin-3-ol ((+)-4), which was prepared by the reductive dynamic optical resolution of the 3-piperidone derivatives ((±)-3) using baker's yeast.

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JO - Chemical Communications

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Asymmetric synthesis of febrifugine and isofebrifugine using yeast reduction

Abstract

ASJC Scopus subject areas

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