Asymmetric synthesis of febrifugine and isofebrifugine using yeast reduction

Y. Takeuchi, K. Azuma, K. Takakura, H. Abe, T. Harayama

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


The antimalarial agents febrifugine ((+)-1) and isofebrifugine ((+)-2) were asymmetrically synthesized from chiral piperidin-3-ol ((+)-4), which was prepared by the reductive dynamic optical resolution of the 3-piperidone derivatives ((±)-3) using baker's yeast.

Original languageEnglish
Pages (from-to)1643-1644
Number of pages2
JournalChemical Communications
Issue number17
Publication statusPublished - Sept 7 2000

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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