Augmentation in cytotoxicity of lymphnode lymphocytes by OK-432

Noriaki Tanaka, Kiyotoshi Gotoh, Genso Kobayashi, Akira Gouchi, Kunzo Orita

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


It has been demonstrated that natural killer (NK) cell activity of lymphnode lymphocytes (LNL) is very low and hardly augmented by interferon. In this study, OK-432 was injected into the gastric cancer mass through endoscopy one week before the operation, through which NK activity of LNL was significantly increased. A single cell assay could divide the OK-432-injected patients into two groups; responder and non-responder. In responders, the increased activity induced by OK-432 was found also in the distal lymphnodes.

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalInternational Journal of Immunopharmacology
Issue number2
Publication statusPublished - Feb 1994
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Pharmacology


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