Augmentation of cytotoxicity of tumor-infiltrating lymphocytes by biological response modifiers

Gotoh Kiyotoshi Gotoh; Gouchi Akira Gouchi; Akura Yosikazu Akura; Tanaka Noriaki Tanaka; Orita Kunzo Orita

doi:10.1016/0192-0561(91)90067-H

Augmentation of cytotoxicity of tumor-infiltrating lymphocytes by biological response modifiers

Gotoh Kiyotoshi Gotoh, Gouchi Akira Gouchi, Akura Yosikazu Akura, Tanaka Noriaki Tanaka, Orita Kunzo Orita

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Lymphocyte infiltration into a tumor has been regarded as an expression of host immunity against cancer, but tumor-infiltrating lymphocytes (TIL) have little or no cytotoxicity. This study examined two different approaches to augment this low cytotoxicity. Firstly, biological response modifiers (OK-432, PSK) were injected into gastric cancer intralesionally. Intralesional injection of OK-432 or PSK significantly augmented the cytotoxicity of TIL. By the injection of OK-432, the ratio of OKT8-, Leu7-positive cells were increased in the TIL subset. In the second approach, TIL of gastric or pulmonary cancer patients were cultured with interleukin-2 (IL-2) in vitro. Co-culturing with IL-2 augmented the low cytotoxicity of TIL, and broad-reactive lymphokine-activated killer (LAK) cells were generated from TIL.

Original language	English
Pages (from-to)	485-492
Number of pages	8
Journal	International Journal of Immunopharmacology
Volume	13
Issue number	5
DOIs	https://doi.org/10.1016/0192-0561(91)90067-H
Publication status	Published - 1991
Externally published	Yes

ASJC Scopus subject areas

Immunology
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0192-0561(91)90067-H

Cite this

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title = "Augmentation of cytotoxicity of tumor-infiltrating lymphocytes by biological response modifiers",

abstract = "Lymphocyte infiltration into a tumor has been regarded as an expression of host immunity against cancer, but tumor-infiltrating lymphocytes (TIL) have little or no cytotoxicity. This study examined two different approaches to augment this low cytotoxicity. Firstly, biological response modifiers (OK-432, PSK) were injected into gastric cancer intralesionally. Intralesional injection of OK-432 or PSK significantly augmented the cytotoxicity of TIL. By the injection of OK-432, the ratio of OKT8-, Leu7-positive cells were increased in the TIL subset. In the second approach, TIL of gastric or pulmonary cancer patients were cultured with interleukin-2 (IL-2) in vitro. Co-culturing with IL-2 augmented the low cytotoxicity of TIL, and broad-reactive lymphokine-activated killer (LAK) cells were generated from TIL.",

author = "{Kiyotoshi Gotoh}, Gotoh and {Akira Gouchi}, Gouchi and {Yosikazu Akura}, Akura and {Noriaki Tanaka}, Tanaka and {Kunzo Orita}, Orita",

year = "1991",

doi = "10.1016/0192-0561(91)90067-H",

language = "English",

volume = "13",

pages = "485--492",

journal = "International Immunopharmacology",

issn = "1567-5769",

publisher = "Elsevier",

number = "5",

}

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T1 - Augmentation of cytotoxicity of tumor-infiltrating lymphocytes by biological response modifiers

AU - Kiyotoshi Gotoh, Gotoh

AU - Akira Gouchi, Gouchi

AU - Yosikazu Akura, Akura

AU - Noriaki Tanaka, Tanaka

AU - Kunzo Orita, Orita

PY - 1991

Y1 - 1991

N2 - Lymphocyte infiltration into a tumor has been regarded as an expression of host immunity against cancer, but tumor-infiltrating lymphocytes (TIL) have little or no cytotoxicity. This study examined two different approaches to augment this low cytotoxicity. Firstly, biological response modifiers (OK-432, PSK) were injected into gastric cancer intralesionally. Intralesional injection of OK-432 or PSK significantly augmented the cytotoxicity of TIL. By the injection of OK-432, the ratio of OKT8-, Leu7-positive cells were increased in the TIL subset. In the second approach, TIL of gastric or pulmonary cancer patients were cultured with interleukin-2 (IL-2) in vitro. Co-culturing with IL-2 augmented the low cytotoxicity of TIL, and broad-reactive lymphokine-activated killer (LAK) cells were generated from TIL.

AB - Lymphocyte infiltration into a tumor has been regarded as an expression of host immunity against cancer, but tumor-infiltrating lymphocytes (TIL) have little or no cytotoxicity. This study examined two different approaches to augment this low cytotoxicity. Firstly, biological response modifiers (OK-432, PSK) were injected into gastric cancer intralesionally. Intralesional injection of OK-432 or PSK significantly augmented the cytotoxicity of TIL. By the injection of OK-432, the ratio of OKT8-, Leu7-positive cells were increased in the TIL subset. In the second approach, TIL of gastric or pulmonary cancer patients were cultured with interleukin-2 (IL-2) in vitro. Co-culturing with IL-2 augmented the low cytotoxicity of TIL, and broad-reactive lymphokine-activated killer (LAK) cells were generated from TIL.

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DO - 10.1016/0192-0561(91)90067-H

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JO - International Immunopharmacology

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Augmentation of cytotoxicity of tumor-infiltrating lymphocytes by biological response modifiers

Abstract

ASJC Scopus subject areas

UN SDGs

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