Abstract
The endoplasmic reticulum chaperone; heat shock protein/rheumatoid arthritis-related antigen (HSP47/RA-A47), in addition to its important intercellular functions for collagen maturation and secretion, has chondrocytes-destructive roles such as induction of endoplasmic reticulum (ER)-stress and metabolic gene expressions result in apoptosis when HSP47/RA-A47 is downregulated. Extracellular HSP47/RA-A47 may act as an autoantigen, but also regulate autoimmune inflammation. It is, therefore, a potential new biologic therapy for rheumatoid arthritis.
| Original language | English |
|---|---|
| Pages (from-to) | 133-136 |
| Number of pages | 4 |
| Journal | Clinical calcium |
| Volume | 16 |
| Issue number | 9 |
| Publication status | Published - Sept 2006 |
ASJC Scopus subject areas
- Medicine(all)