Autoimmune neutropenia associated with multiple sclerosis

Teruhiko Kozuka, Kensuke Kojima, Kinuyo Kaneda, Katsuto Takenaka, Yasuhiro Manabe, Yasushi Hirata, Shigenori Okuma, Hironobu Toki, Mitsune Tanimoto

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


A 53-year-old Japanese man with multiple sclerosis developed autoimmune neutropenia. The neutrophil count was consistently less than 0.2×109/l, irrespective of the disease activity of multiple sclerosis or the administration of immunosuppressive agents or granulocyte colony-stimulating factor. After high-dose γ-globulin therapy was started, temporary increases in the neutrophil count were observed. Despite a wide spectrum of clinical manifestations in multiple sclerosis, autoimmune neutropenia has never been reported previously.

Original languageEnglish
Pages (from-to)102-104
Number of pages3
JournalInternal Medicine
Issue number1
Publication statusPublished - Jan 1 2003
Externally publishedYes


  • Autoimmune neutropenia
  • Cyclosporine
  • Multiple sclerosis
  • Neutrophil antibody

ASJC Scopus subject areas

  • Internal Medicine


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