Autologous Bone Marrow Transplantation for Polymyositis Combined with Myasthenia Gravis and Aplastic Anemia: A Case Report

Sho Mitsumune; Yasuhiro Manabe; Taijun Yunoki; Shyoichiro Kono; Kazutoshi Aoyama; Yoko Shinno; Hisashi Narai; Koji Abe

doi:10.1159/000488476

Autologous Bone Marrow Transplantation for Polymyositis Combined with Myasthenia Gravis and Aplastic Anemia: A Case Report

Sho Mitsumune, Yasuhiro Manabe, Taijun Yunoki, Shyoichiro Kono, Kazutoshi Aoyama, Yoko Shinno, Hisashi Narai, Koji Abe

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

This is the first report about a patient with concomitant polymyositis (PM), myasthenia gravis (MG), and aplastic anemia (AA). A 54-year-old male developed myalgia and muscle weakness, which gradually progressed over 2 months. He was persistently affected by MG and AA. Brachium magnetic resonance imaging showed increased signal intensity in the left triceps and deltoid muscles on short tau inversion recovery images. A muscle biopsy examination revealed perifascicular atrophication and inflammatory myopathy. We diagnosed the patient with PM combined with MG and AA. He was successfully treated with an autologous bone marrow transplantation (BMT). The present case suggests that BMT is a therapeutic option for PM, MG, and AA.

Original language	English
Pages (from-to)	108-111
Number of pages	4
Journal	Case Reports in Neurology
Volume	10
Issue number	1
DOIs	https://doi.org/10.1159/000488476
Publication status	Published - Feb 14 2018

Keywords

Aplastic anemia
Bone marrow transplantation
Myasthenia gravis
Polymyositis

ASJC Scopus subject areas

Clinical Neurology

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10.1159/000488476

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title = "Autologous Bone Marrow Transplantation for Polymyositis Combined with Myasthenia Gravis and Aplastic Anemia: A Case Report",

abstract = "This is the first report about a patient with concomitant polymyositis (PM), myasthenia gravis (MG), and aplastic anemia (AA). A 54-year-old male developed myalgia and muscle weakness, which gradually progressed over 2 months. He was persistently affected by MG and AA. Brachium magnetic resonance imaging showed increased signal intensity in the left triceps and deltoid muscles on short tau inversion recovery images. A muscle biopsy examination revealed perifascicular atrophication and inflammatory myopathy. We diagnosed the patient with PM combined with MG and AA. He was successfully treated with an autologous bone marrow transplantation (BMT). The present case suggests that BMT is a therapeutic option for PM, MG, and AA.",

keywords = "Aplastic anemia, Bone marrow transplantation, Myasthenia gravis, Polymyositis",

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T2 - A Case Report

AU - Mitsumune, Sho

AU - Manabe, Yasuhiro

AU - Yunoki, Taijun

AU - Kono, Shyoichiro

AU - Aoyama, Kazutoshi

AU - Shinno, Yoko

AU - Narai, Hisashi

AU - Abe, Koji

PY - 2018/2/14

Y1 - 2018/2/14

N2 - This is the first report about a patient with concomitant polymyositis (PM), myasthenia gravis (MG), and aplastic anemia (AA). A 54-year-old male developed myalgia and muscle weakness, which gradually progressed over 2 months. He was persistently affected by MG and AA. Brachium magnetic resonance imaging showed increased signal intensity in the left triceps and deltoid muscles on short tau inversion recovery images. A muscle biopsy examination revealed perifascicular atrophication and inflammatory myopathy. We diagnosed the patient with PM combined with MG and AA. He was successfully treated with an autologous bone marrow transplantation (BMT). The present case suggests that BMT is a therapeutic option for PM, MG, and AA.

AB - This is the first report about a patient with concomitant polymyositis (PM), myasthenia gravis (MG), and aplastic anemia (AA). A 54-year-old male developed myalgia and muscle weakness, which gradually progressed over 2 months. He was persistently affected by MG and AA. Brachium magnetic resonance imaging showed increased signal intensity in the left triceps and deltoid muscles on short tau inversion recovery images. A muscle biopsy examination revealed perifascicular atrophication and inflammatory myopathy. We diagnosed the patient with PM combined with MG and AA. He was successfully treated with an autologous bone marrow transplantation (BMT). The present case suggests that BMT is a therapeutic option for PM, MG, and AA.

KW - Aplastic anemia

KW - Bone marrow transplantation

KW - Myasthenia gravis

KW - Polymyositis

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Autologous Bone Marrow Transplantation for Polymyositis Combined with Myasthenia Gravis and Aplastic Anemia: A Case Report

Abstract

Keywords

ASJC Scopus subject areas

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