TY - JOUR
T1 - Bacteremia due to high-level daptomycin-resistant Corynebacterium striatum
T2 - A case report with genetic investigation
AU - Hagiya, Hideharu
AU - Kimura, Keigo
AU - Okuno, Hideo
AU - Hamaguchi, Shigeto
AU - Morii, Daiichi
AU - Yoshida, Hisao
AU - Mitsui, Tomomi
AU - Nishi, Isao
AU - Tomono, Kazunori
PY - 2019/11
Y1 - 2019/11
N2 - Corynebacterium striatum, generally considered an opportunistic organism in humans, has recently been known to develop high-level daptomycin resistance (HLDR) shortly after drug exposure. To date, however, only several such clinical isolates have been described in the literature and clinical background of the resistant pathogen remains to be elucidated. Here, we report a case involving a C. striatum strain with HLDR harboring novel nucleotide mutations, together with a review of the relevant literature. To the best of our knowledge, this is the first well-investigated clinical report from Japan including a genetic investigation. Considering the rapid emergence of HLDR C. striatum in vitro experiment, there could be a number of underreporting cases. Scrupulous attention is required when administering daptomycin for the treatment of C. striatum infections, even if the organism has initially exhibited susceptibility.
AB - Corynebacterium striatum, generally considered an opportunistic organism in humans, has recently been known to develop high-level daptomycin resistance (HLDR) shortly after drug exposure. To date, however, only several such clinical isolates have been described in the literature and clinical background of the resistant pathogen remains to be elucidated. Here, we report a case involving a C. striatum strain with HLDR harboring novel nucleotide mutations, together with a review of the relevant literature. To the best of our knowledge, this is the first well-investigated clinical report from Japan including a genetic investigation. Considering the rapid emergence of HLDR C. striatum in vitro experiment, there could be a number of underreporting cases. Scrupulous attention is required when administering daptomycin for the treatment of C. striatum infections, even if the organism has initially exhibited susceptibility.
KW - Antimicrobial resistance
KW - Corynebacterium
KW - Daptomycin
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U2 - 10.1016/j.jiac.2019.04.009
DO - 10.1016/j.jiac.2019.04.009
M3 - Article
C2 - 31101531
AN - SCOPUS:85065479722
SN - 1341-321X
VL - 25
SP - 906
EP - 908
JO - Journal of Infection and Chemotherapy
JF - Journal of Infection and Chemotherapy
IS - 11
ER -
