Basic and clinical studies on biapenem in genito-urinary infections

Toyohiko Watanabe; Tadasu Takenaka; Toshihide Hayashi; Kazuhiro Hata; Noriaki Ono; Hiromi Kumon; Hiroyuki Ohmori; Keigo Kinugawa; Hiroyoshi Tanaka; Mototaka Takada; Katsuichi Nanba; Katsuji Takeda; Toshihiko Asahi; Satoshi Uno; Taiichiro Jousen

doi:10.11250/chemotherapy1953.42.Supplement4_486

Basic and clinical studies on biapenem in genito-urinary infections

Toyohiko Watanabe, Tadasu Takenaka, Toshihide Hayashi, Kazuhiro Hata, Noriaki Ono, Hiromi Kumon, Hiroyuki Ohmori, Keigo Kinugawa, Hiroyoshi Tanaka, Mototaka Takada, Katsuichi Nanba, Katsuji Takeda, Toshihiko Asahi, Satoshi Uno, Taiichiro Jousen

Research output: Contribution to journal › Article › peer-review

Abstract

We studied the antibacterial activity and clinical efficacy of biapenem (BIPM), a new carbapenem antibiotic, in the genito-urinary, infections. 1) Antibacterial activity: We measured the MICs of BIPM against clinical isolates (210 strains of 14 species) from urinary tract infections, and compared them with those of imipenem (IPM), ceftazidime (CAZ), latamoxef (LMOX) and cefoperazone (CPZ). In general, antibacterial activities of BIPM were almost equal to those of IPM, but superior to those of other control drugs. 2) Clinical efficacy: According to the criteria of Japanese UTI committee, the overall clinical efficacy rate was 73.9%(17/23) for chronic complicated UTI. Bacteriologically, 30 of 35 strains (85.7%) were eradicated. 3) Side effect: Clinical side effects and abnormal laboratory changes were not observed in any cases.

Original language	English
Pages (from-to)	486-496
Number of pages	11
Journal	CHEMOTHERAPY
Volume	42
DOIs	https://doi.org/10.11250/chemotherapy1953.42.Supplement4_486
Publication status	Published - 1994

Keywords

Biapenem

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology
Drug Discovery
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.11250/chemotherapy1953.42.Supplement4_486

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title = "Basic and clinical studies on biapenem in genito-urinary infections",

abstract = "We studied the antibacterial activity and clinical efficacy of biapenem (BIPM), a new carbapenem antibiotic, in the genito-urinary, infections. 1) Antibacterial activity: We measured the MICs of BIPM against clinical isolates (210 strains of 14 species) from urinary tract infections, and compared them with those of imipenem (IPM), ceftazidime (CAZ), latamoxef (LMOX) and cefoperazone (CPZ). In general, antibacterial activities of BIPM were almost equal to those of IPM, but superior to those of other control drugs. 2) Clinical efficacy: According to the criteria of Japanese UTI committee, the overall clinical efficacy rate was 73.9%(17/23) for chronic complicated UTI. Bacteriologically, 30 of 35 strains (85.7%) were eradicated. 3) Side effect: Clinical side effects and abnormal laboratory changes were not observed in any cases.",

keywords = "Biapenem",

author = "Toyohiko Watanabe and Tadasu Takenaka and Toshihide Hayashi and Kazuhiro Hata and Noriaki Ono and Hiromi Kumon and Hiroyuki Ohmori and Keigo Kinugawa and Hiroyoshi Tanaka and Mototaka Takada and Katsuichi Nanba and Katsuji Takeda and Toshihiko Asahi and Satoshi Uno and Taiichiro Jousen",

year = "1994",

doi = "10.11250/chemotherapy1953.42.Supplement4_486",

language = "English",

volume = "42",

pages = "486--496",

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T1 - Basic and clinical studies on biapenem in genito-urinary infections

AU - Watanabe, Toyohiko

AU - Takenaka, Tadasu

AU - Hayashi, Toshihide

AU - Hata, Kazuhiro

AU - Ono, Noriaki

AU - Kumon, Hiromi

AU - Ohmori, Hiroyuki

AU - Kinugawa, Keigo

AU - Tanaka, Hiroyoshi

AU - Takada, Mototaka

AU - Nanba, Katsuichi

AU - Takeda, Katsuji

AU - Asahi, Toshihiko

AU - Uno, Satoshi

AU - Jousen, Taiichiro

PY - 1994

Y1 - 1994

N2 - We studied the antibacterial activity and clinical efficacy of biapenem (BIPM), a new carbapenem antibiotic, in the genito-urinary, infections. 1) Antibacterial activity: We measured the MICs of BIPM against clinical isolates (210 strains of 14 species) from urinary tract infections, and compared them with those of imipenem (IPM), ceftazidime (CAZ), latamoxef (LMOX) and cefoperazone (CPZ). In general, antibacterial activities of BIPM were almost equal to those of IPM, but superior to those of other control drugs. 2) Clinical efficacy: According to the criteria of Japanese UTI committee, the overall clinical efficacy rate was 73.9%(17/23) for chronic complicated UTI. Bacteriologically, 30 of 35 strains (85.7%) were eradicated. 3) Side effect: Clinical side effects and abnormal laboratory changes were not observed in any cases.

AB - We studied the antibacterial activity and clinical efficacy of biapenem (BIPM), a new carbapenem antibiotic, in the genito-urinary, infections. 1) Antibacterial activity: We measured the MICs of BIPM against clinical isolates (210 strains of 14 species) from urinary tract infections, and compared them with those of imipenem (IPM), ceftazidime (CAZ), latamoxef (LMOX) and cefoperazone (CPZ). In general, antibacterial activities of BIPM were almost equal to those of IPM, but superior to those of other control drugs. 2) Clinical efficacy: According to the criteria of Japanese UTI committee, the overall clinical efficacy rate was 73.9%(17/23) for chronic complicated UTI. Bacteriologically, 30 of 35 strains (85.7%) were eradicated. 3) Side effect: Clinical side effects and abnormal laboratory changes were not observed in any cases.

KW - Biapenem

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EP - 496

JO - Chemotherapy

JF - Chemotherapy

ER -

Basic and clinical studies on biapenem in genito-urinary infections

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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