TY - JOUR
T1 - Basic and clinical studies on FK037 in complicated urinary tract infections
AU - Watanabe, Toyohiko
AU - Takenaka, Tadasu
AU - Hayashi, Toshihide
AU - Sakuramoto, Koushi
AU - Hata, Kazuhiro
AU - Ono, Noriaki
AU - Kumon, Hiromi
AU - Ohmori, Hiroyuki
AU - Katayama, Yasuhiro
AU - Yamashita, Yoshitaka
AU - Akaeda, Teruaki
PY - 1994/1/1
Y1 - 1994/1/1
N2 - We studied the antibacterial activity and efficacy of FK037, a new injectable cephem antibiotic, in the urological field. 1) Antibacterial activity: The MICs of FK037 were measured against 211 clinically isolated strains of 14 species from urinary tract infections and compared with those of ceftazidime (CAZ), cefoperazone (CPZ) and imipenem (IPM). In general, the antibacterial activities of FK037 were superior to those of CAZ and CPZ, but inferior to those of IPM. 2) Clinical efficacy: According to the criteria of Japanese UTI Committee, the overall clinical efficacy rate was 75.0%(9/12) for chronic complicated UTI. Bacteriologically, 18 of 20 strains (90.0%) isolated were eradicated. 3) Side effect: A mild and transient rash was observed in 1 patient. In 1 patient, eosinophilia was noted, but was not problematic clinically. Based on the above findings, FK037 might be useful in the treatment of urinary tract infection.
AB - We studied the antibacterial activity and efficacy of FK037, a new injectable cephem antibiotic, in the urological field. 1) Antibacterial activity: The MICs of FK037 were measured against 211 clinically isolated strains of 14 species from urinary tract infections and compared with those of ceftazidime (CAZ), cefoperazone (CPZ) and imipenem (IPM). In general, the antibacterial activities of FK037 were superior to those of CAZ and CPZ, but inferior to those of IPM. 2) Clinical efficacy: According to the criteria of Japanese UTI Committee, the overall clinical efficacy rate was 75.0%(9/12) for chronic complicated UTI. Bacteriologically, 18 of 20 strains (90.0%) isolated were eradicated. 3) Side effect: A mild and transient rash was observed in 1 patient. In 1 patient, eosinophilia was noted, but was not problematic clinically. Based on the above findings, FK037 might be useful in the treatment of urinary tract infection.
KW - FK037
UR - http://www.scopus.com/inward/record.url?scp=0028032339&partnerID=8YFLogxK
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U2 - 10.11250/chemotherapy1953.42.Supplement3_260
DO - 10.11250/chemotherapy1953.42.Supplement3_260
M3 - Article
AN - SCOPUS:0028032339
SN - 0009-3165
VL - 42
SP - 260
EP - 268
JO - CHEMOTHERAPY
JF - CHEMOTHERAPY
ER -
