TY - JOUR
T1 - Basic and clinical studies on grepafloxacin in the urological fiel
AU - Takenaka, Tadasu
AU - Watanabe, Toyohiko
AU - Sakuramoto, Kohji
AU - Hayashi, Toshihide
AU - Hata, Kazuhiro
AU - Ono, Noriaki
AU - Kumon, Hiromi
AU - Ohmori, Hiroyuki
AU - Katayama, Yasuhiro
AU - Mizuno, Akihiro
AU - Kishi, Mikio
AU - Nasu, Ryoji
PY - 1995/1/1
Y1 - 1995/1/1
N2 - We studied the antibacterial activity and clinical usefulness of grepafloxacin (GPFX), a new quinolone, in the urological field. 1) Antibacterial activity: The MICs of GPFX were measured against 210 clinical isolates of 14 species from urinary tract infection and compared with those of ofloxacin (OFLX), ciprofloxacin (CPFX) and norfloxacin (NFLX). In general, the antibacterial activity of GPFX was inferior to CPFX, but equal or superior to those of other control drugs. 2) Clinical efficacy: Although the clinical efficacy in acute uncomplicated cystitis and chronic bacterial prostatitis was good, the overall clinical efficacy rate according to the criteria of the UTI Committee was 36.4%(8/22) in chronic complicated UTI. Fifteen of 25 (60%) strains isolated were eradicated. 3) Side effects: Temporary discomfort of the left side of the body was observed in one case. Mild elevation of eosinophils or GOT·GPT was observed in one case.
AB - We studied the antibacterial activity and clinical usefulness of grepafloxacin (GPFX), a new quinolone, in the urological field. 1) Antibacterial activity: The MICs of GPFX were measured against 210 clinical isolates of 14 species from urinary tract infection and compared with those of ofloxacin (OFLX), ciprofloxacin (CPFX) and norfloxacin (NFLX). In general, the antibacterial activity of GPFX was inferior to CPFX, but equal or superior to those of other control drugs. 2) Clinical efficacy: Although the clinical efficacy in acute uncomplicated cystitis and chronic bacterial prostatitis was good, the overall clinical efficacy rate according to the criteria of the UTI Committee was 36.4%(8/22) in chronic complicated UTI. Fifteen of 25 (60%) strains isolated were eradicated. 3) Side effects: Temporary discomfort of the left side of the body was observed in one case. Mild elevation of eosinophils or GOT·GPT was observed in one case.
KW - grepafloxacin
UR - http://www.scopus.com/inward/record.url?scp=0029096361&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029096361&partnerID=8YFLogxK
U2 - 10.11250/chemotherapy1995.43.Supplement1_397
DO - 10.11250/chemotherapy1995.43.Supplement1_397
M3 - Article
AN - SCOPUS:0029096361
SN - 1340-7007
VL - 43
SP - 397
EP - 404
JO - Japanese Journal of Chemotherapy
JF - Japanese Journal of Chemotherapy
ER -