Beneficial effects of fermented green tea extract in a rat model of non-alcoholic steatohepatitis

Kazuo Nakamoto, Fusako Takayama, Mitsumasa Mankura, Yuki Hidaka, Toru Egashira, Tetsuya Ogino, Hiromu Kawasaki, Akitane Mori

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)


Oxidative stress is frequently considered as a central mechanism of hepatocellular injury in non-alcoholic steatohepatitis (NASH). The aim of this study was to investigate the effects of fermented green tea extracts (FGTE) on NASH. Rats were fed a choline-deficient high-fat diet for 4 weeks to nutritionally generate fatty livers. NASH was induced chemically by oxidative stress using repeated intraperitoneal injections of nitrite. Rats with NASH developed steatohepatitis and liver fibrosis after 6-week of such treatment. At 10 weeks, blood and liver samples were collected from anesthetized animals and assessed for extent of OS injury and effects of FGTE, by biochemical, histological and histochemical analyses. FGTE reduced serum levels of liver enzymes, lipid peroxidation and production of mitochondrial reactive oxygen species. In addition, FGTE showed inhibition of progressions of cirrhosis. Our findings suggest that our FGTE have strong radical scavenging activity and may be beneficial in the prevention of NASH progression.

Original languageEnglish
Pages (from-to)239-246
Number of pages8
Journaljournal of clinical biochemistry and nutrition
Issue number3
Publication statusPublished - May 2009
Externally publishedYes


  • Antioxidant
  • Hepatoprotection
  • Non-alcoholic steatohepatitis
  • Oxidative stress

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry


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