TY - JOUR
T1 - Biliary excretion of essential trace elements in rats under oxidative stress caused by selenium deficiency
AU - Yamasaki, Kosuke
AU - Sakuma, Yasunobu
AU - Sasaki, Junya
AU - Matsumoto, Ken Ichiro
AU - Anzai, Kazunori
AU - Matsuoka, Keisuke
AU - Honda, Chikako
AU - Tsukada, Masamichi
AU - Endo, Kazutoyo
AU - Enomoto, Shuichi
N1 - Funding Information:
Acknowledgments We are grateful to the staff of the RIKEN Ring Cyclotron for their help with heavy-ion irradiation, and also the staff of the Open Laboratory, The University of Tokyo, for the use of the JRR-4 nuclear reactor at the Japan Atomic Energy Agency (Tokai, Japan). The work was supported by a grant-in-aid for the Scientific Research C from the Japan Society for promotion of Science.
PY - 2011/11
Y1 - 2011/11
N2 - The excretion of essential trace elements, namely, Se, Sr, As, Mn, Co, V, Fe, and Zn into the bile of Se-deficient (SeD) Wistar male rats was studied using the multitracer (MT) technique, and instrumental neutron activation analysis (INAA). Normal and Se-control (SeC) rat groups were used as reference groups to compare the effects of Se levels on the behaviors of the essential trace elements. The excretion (% dose) of Se, Sr, As, Mn, Co, and V increased with Se levels in the liver. The biliary excretion of Mn and As dramatically enhanced for SeC rats compared with SeD rats, while that of V accelerated a little for SeC rats. The radioactivity levels of 59Fe and 65Zn in the MT tracer solution were insufficient to measure their excretion into bile. The role of glutathione and bilirubin for biliary excretion of the metals was discussed in relation to Se levels in rat liver. [Figure not available: see fulltext.]
AB - The excretion of essential trace elements, namely, Se, Sr, As, Mn, Co, V, Fe, and Zn into the bile of Se-deficient (SeD) Wistar male rats was studied using the multitracer (MT) technique, and instrumental neutron activation analysis (INAA). Normal and Se-control (SeC) rat groups were used as reference groups to compare the effects of Se levels on the behaviors of the essential trace elements. The excretion (% dose) of Se, Sr, As, Mn, Co, and V increased with Se levels in the liver. The biliary excretion of Mn and As dramatically enhanced for SeC rats compared with SeD rats, while that of V accelerated a little for SeC rats. The radioactivity levels of 59Fe and 65Zn in the MT tracer solution were insufficient to measure their excretion into bile. The role of glutathione and bilirubin for biliary excretion of the metals was discussed in relation to Se levels in rat liver. [Figure not available: see fulltext.]
KW - Bile
KW - Biliary excretion
KW - Essential trace element
KW - Glutathione
KW - Glutathione peroxidase
KW - INAA
KW - Multitracer
KW - Oxidative stress
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U2 - 10.1007/s00216-011-5333-4
DO - 10.1007/s00216-011-5333-4
M3 - Article
C2 - 21870070
AN - SCOPUS:80255136350
SN - 1618-2642
VL - 401
SP - 2531
EP - 2538
JO - Analytical and Bioanalytical Chemistry
JF - Analytical and Bioanalytical Chemistry
IS - 8
ER -