Biliary excretion of essential trace elements in rats under oxidative stress caused by selenium deficiency

Kosuke Yamasaki, Yasunobu Sakuma, Junya Sasaki, Ken Ichiro Matsumoto, Kazunori Anzai, Keisuke Matsuoka, Chikako Honda, Masamichi Tsukada, Kazutoyo Endo, Shuichi Enomoto

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


The excretion of essential trace elements, namely, Se, Sr, As, Mn, Co, V, Fe, and Zn into the bile of Se-deficient (SeD) Wistar male rats was studied using the multitracer (MT) technique, and instrumental neutron activation analysis (INAA). Normal and Se-control (SeC) rat groups were used as reference groups to compare the effects of Se levels on the behaviors of the essential trace elements. The excretion (% dose) of Se, Sr, As, Mn, Co, and V increased with Se levels in the liver. The biliary excretion of Mn and As dramatically enhanced for SeC rats compared with SeD rats, while that of V accelerated a little for SeC rats. The radioactivity levels of 59Fe and 65Zn in the MT tracer solution were insufficient to measure their excretion into bile. The role of glutathione and bilirubin for biliary excretion of the metals was discussed in relation to Se levels in rat liver. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)2531-2538
Number of pages8
JournalAnalytical and Bioanalytical Chemistry
Issue number8
Publication statusPublished - Nov 2011


  • Bile
  • Biliary excretion
  • Essential trace element
  • Glutathione
  • Glutathione peroxidase
  • INAA
  • Multitracer
  • Oxidative stress

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


Dive into the research topics of 'Biliary excretion of essential trace elements in rats under oxidative stress caused by selenium deficiency'. Together they form a unique fingerprint.

Cite this