Bioactive macrolides and polyketides from marine dinoflagellates

Jun'ichi Kobayashi, Kazutaka Shimbo, Takaaki Kubota, Masashi Tsuda

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66 Citations (Scopus)


Absolute stereochemistry of amphidinolides G and H, potent cytotoxic 27- and 26-membered macrolides, respectively, isolated from a marine dinofiagellate Amphidinium sp., was determined by X-ray diffraction analysis, synthesis of a degradation product, and chemical interconversion. Six new macrolides, amphidinolides H2∼H5, G2, G3, and W, have been isolated from a marine dinoflagellate Amphidinium sp. (strain Y-42), and the structures were elucidated by 2D NMR data and chemical means. The structure-activity relationship of amphidinolide H-type macrolides for cytotoxicity was examined. The biosynthetic origins of amphidinolides B, C, H, J, T1, and W were investigated on the basis of 13C NMR data of 13C-enriched samples obtained by feeding experiments with [1-13C], [2-13C], and [1,2-13C2] sodium acetates in cultures of the dinoflagellates. Five novel long-chain polyhydroxyl compounds, colopsinols A∼E, were obtained from the Amphidinium sp. (strain Y-5).

Original languageEnglish
Pages (from-to)337-342
Number of pages6
JournalPure and Applied Chemistry
Issue number2-3
Publication statusPublished - 2003
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)


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