Bioactivity of titanium treated with hydrogen peroxide solutions containing metal chlorides

Chikara Ohtsuki, Hirohisa Iida, Satoshi Hayakawa, Akiyoshi Osaka

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226 Citations (Scopus)


Commercially available pure metallic titanium was chemically treated at 60°C for 24 h with H2O2 solutions containing various metal chlorides to provide titanium with bioactivity, that is, to give it the ability to form a biologically active bone-like apatite layer on the surface. After the chemical treatment the titanium specimens were soaked in a simulated body fluid (the Kokubo solution). Apatite was found to deposit on the specimens treated with the H2O2/TaCl5 and H2O2/SnCl2 solutions. X-ray photoelectron spectroscopic (XPS) study of the specimens treated with those H2O2 solutions indicated that basic Ti-OH groups in titania hydrogel layers on their surfaces were responsible for apatite nucleation and growth.

Original languageEnglish
Pages (from-to)39-47
Number of pages9
JournalJournal of Biomedical Materials Research
Issue number1
Publication statusPublished - Apr 1997

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


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