Biological safety of hydrogen

Qiang Sun, Wenjie Han, Atsunori Nakao

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)


Based on three main reasons, the biosafety of hydrogen is very high: The first is evidence from medical research on hydrogen diving, the second is that hydrogen is an endogenous gas, and the third is direct research on the biosafety of hydrogen. Research on hydrogen diving, combined with human trials on hydrogen diving, proved that hydrogen is very safe for humans to breathe. Since a certain level of hydrogen is produced by Escherichia coli in the large intestine of normal humans, hydrogen can be considered an endogenous gas. So far, no clinical evidence has been found that hydrogen can be harmful for the human body. Published data from the EU and the US government on the biosafety of hydrogen showed that hydrogen has no acute or chronic toxicity on the human body under normal pressure. Despite this, any substance that can produce biological effects on the human body has the potential of destroying homeostasis, which may be harmful. Although the biosafety of hydrogen is very high, we still cannot assure that hydrogen has no side effects on the human body.

Original languageEnglish
Title of host publicationHydrogen Molecular Biology and Medicine
PublisherSpringer Netherlands
Number of pages14
ISBN (Electronic)9789401796910
ISBN (Print)9789401796903
Publication statusPublished - Jan 1 2015
Externally publishedYes


  • Biosafety
  • Diving
  • Endogenous gas
  • Hydrogen
  • Narcotic effect

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • General Medicine


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