Abstract
A chemical model system for cytochrome P-450, consisting of tetraphenylporphyrin manganese chloride (TPPMnCl) and iodosylbenzene, efficiently oxidized 2-methylimidazole to 2-methylimidazolone. This system next applied to 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutyramide, a muscarinic acetylcholine receptor antagonist under clinical trial, affording the previously unisolated imidazole ring 5-mono-oxidized derivative that considered to be the precursor of the main metabolites. This system, which is superior to the copper-ascorbate system, should be applicable to in vitro studies of various drugs containing the 2-methylimidazole moiety.
| Original language | English |
|---|---|
| Pages (from-to) | 1137-1140 |
| Number of pages | 4 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 50 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2002 |
Keywords
- 2-methylimidazole derivative
- 2-methylimidazolone derivative
- Drug metabolism
- Metabolic intermediate
- Metalloporphyrin
- P-450 Chemical model
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery