Biosynthetic study of amphidinolide B

M. Tsuda, T. Kubota, Y. Sakuma, J. Kobayashi

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24 Citations (Scopus)


The biosynthetic origins of amphidinolide B (1) were investigated on the basis of 13C-NMR data of 13C-enriched samples obtained by feeding experiments with [1-13C], [2-13C], and [1,2-13C2] sodium acetates in cultures of a dinoflagellate Amphidinium sp. These incorporation patterns suggested that 1 was generated from three successive polyketide chains, an isolated C1 unit from C-2 of acetates, six branched C1 units from C-2 of acetates, and an "m-m" and an "m-m-m" unit derived only from C-2 of acetates. The labeling patterns of amphidinolide B (1) were different from those of amphidinolide H (2), a 26-membered macrolide closely related to 1.

Original languageEnglish
Pages (from-to)1366-1367
Number of pages2
JournalChemical and Pharmaceutical Bulletin
Issue number10
Publication statusPublished - 2001
Externally publishedYes


  • Biosynthesis
  • Macrolide
  • Marine dinoflagellate

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery


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