Biosynthetic study of amphidinolide C

Takaaki Kubota; Masashi Tsuda; Jun'ichi Kobayashi

doi:10.1016/S0040-4020(01)00556-7

Biosynthetic study of amphidinolide C

Takaaki Kubota, Masashi Tsuda, Jun'ichi Kobayashi

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The biosynthetic origins of amphidinolide C (1) were investigated on the basis of ¹³C NMR data of ¹³C enriched samples obtained by feeding experiments with [1-¹³C], [2-¹³C], and [1,2-¹³C₂] sodium acetates in cultures of a dinoflagellate Amphidinium sp. These incorporation patterns suggested that amphidinolide C (1) was generated from four diketide chains, four acetate units, five isolated C₁ unit from C-2 of acetates, seven branched C₁ units from C-2 of acetates, and a 'm-m' and a 'm-m-m' units derived only from C-2 of acetates.

Original language	English
Pages (from-to)	5975-5977
Number of pages	3
Journal	Tetrahedron
Volume	57
Issue number	28
DOIs	https://doi.org/10.1016/S0040-4020(01)00556-7
Publication status	Published - Jul 9 2001
Externally published	Yes

Keywords

Biosynthesis
Dinoflagellate
Macrolide

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4020(01)00556-7

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@article{db4bb4fcf3d54aca91e5ae2e74d47ef8,

title = "Biosynthetic study of amphidinolide C",

abstract = "The biosynthetic origins of amphidinolide C (1) were investigated on the basis of 13C NMR data of 13C enriched samples obtained by feeding experiments with [1-13C], [2-13C], and [1,2-13C2] sodium acetates in cultures of a dinoflagellate Amphidinium sp. These incorporation patterns suggested that amphidinolide C (1) was generated from four diketide chains, four acetate units, five isolated C1 unit from C-2 of acetates, seven branched C1 units from C-2 of acetates, and a 'm-m' and a 'm-m-m' units derived only from C-2 of acetates.",

keywords = "Biosynthesis, Dinoflagellate, Macrolide",

author = "Takaaki Kubota and Masashi Tsuda and Jun'ichi Kobayashi",

note = "Funding Information: We thank Professor T. Yamasu, University of the Ryukyus, and Dr M. Ishibashi for help with dinoflagellate collection. This work was partly supported by a Grant-in-aid from the Japan Securities Scholarship Foundation, a Grant-in-aid from Uehara Memorial Foundation, and a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan.",

year = "2001",

month = jul,

day = "9",

doi = "10.1016/S0040-4020(01)00556-7",

language = "English",

volume = "57",

pages = "5975--5977",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Limited",

number = "28",

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TY - JOUR

T1 - Biosynthetic study of amphidinolide C

AU - Kubota, Takaaki

AU - Tsuda, Masashi

AU - Kobayashi, Jun'ichi

N1 - Funding Information: We thank Professor T. Yamasu, University of the Ryukyus, and Dr M. Ishibashi for help with dinoflagellate collection. This work was partly supported by a Grant-in-aid from the Japan Securities Scholarship Foundation, a Grant-in-aid from Uehara Memorial Foundation, and a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan.

PY - 2001/7/9

Y1 - 2001/7/9

N2 - The biosynthetic origins of amphidinolide C (1) were investigated on the basis of 13C NMR data of 13C enriched samples obtained by feeding experiments with [1-13C], [2-13C], and [1,2-13C2] sodium acetates in cultures of a dinoflagellate Amphidinium sp. These incorporation patterns suggested that amphidinolide C (1) was generated from four diketide chains, four acetate units, five isolated C1 unit from C-2 of acetates, seven branched C1 units from C-2 of acetates, and a 'm-m' and a 'm-m-m' units derived only from C-2 of acetates.

AB - The biosynthetic origins of amphidinolide C (1) were investigated on the basis of 13C NMR data of 13C enriched samples obtained by feeding experiments with [1-13C], [2-13C], and [1,2-13C2] sodium acetates in cultures of a dinoflagellate Amphidinium sp. These incorporation patterns suggested that amphidinolide C (1) was generated from four diketide chains, four acetate units, five isolated C1 unit from C-2 of acetates, seven branched C1 units from C-2 of acetates, and a 'm-m' and a 'm-m-m' units derived only from C-2 of acetates.

KW - Biosynthesis

KW - Dinoflagellate

KW - Macrolide

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UR - http://www.scopus.com/inward/citedby.url?scp=0035833081&partnerID=8YFLogxK

U2 - 10.1016/S0040-4020(01)00556-7

DO - 10.1016/S0040-4020(01)00556-7

M3 - Article

AN - SCOPUS:0035833081

SN - 0040-4020

VL - 57

SP - 5975

EP - 5977

JO - Tetrahedron

JF - Tetrahedron

IS - 28

ER -

Biosynthetic study of amphidinolide C

Abstract

Keywords

ASJC Scopus subject areas

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