TY - JOUR
T1 - Boron analysis and boron imaging in biological materials for Boron Neutron Capture Therapy (BNCT)
AU - Wittig, Andrea
AU - Michel, Jean
AU - Moss, Raymond L.
AU - Stecher-Rasmussen, Finn
AU - Arlinghaus, Heinrich F.
AU - Bendel, Peter
AU - Mauri, Pier Luigi
AU - Altieri, Saverio
AU - Hilger, Ralf
AU - Salvadori, Piero A.
AU - Menichetti, Luca
AU - Zamenhof, Robert
AU - Sauerwein, Wolfgang A.G.
N1 - Funding Information:
This work has been financially supported by the European Commission Contract No. QLK3-CT-1999-01067 (FP5) and 005045 (FP6), by the Swiss foundation “Neurochiriugie 2001”, by a grant from the G.I.F., the German-Israeli Foundation for Scientific Research, by the German research ministry BMBF under Contract No. 13N8021, and by joint public grants from “Ministero, dell’Università e della Ricerca” (Project RBIN04XCJX). All grants are gratefully acknowledged.
PY - 2008/10
Y1 - 2008/10
N2 - Boron Neutron Capture Therapy (BNCT) is based on the ability of the stable isotope 10B to capture neutrons, which leads to a nuclear reaction producing an alpha- and a 7Li-particle, both having a high biological effectiveness and a very short range in tissue, being limited to approximately one cell diameter. This opens the possibility for a highly selective cancer therapy. BNCT strongly depends on the selective uptake of 10B in tumor cells and on its distribution inside the cells. The chemical properties of boron and the need to discriminate different isotopes make the investigation of the concentration and distribution of 10B a challenging task. The most advanced techniques to measure and image boron are described, both invasive and non-invasive. The most promising approach for further investigation will be the complementary use of the different techniques to obtain the information that is mandatory for the future of this innovative treatment modality.
AB - Boron Neutron Capture Therapy (BNCT) is based on the ability of the stable isotope 10B to capture neutrons, which leads to a nuclear reaction producing an alpha- and a 7Li-particle, both having a high biological effectiveness and a very short range in tissue, being limited to approximately one cell diameter. This opens the possibility for a highly selective cancer therapy. BNCT strongly depends on the selective uptake of 10B in tumor cells and on its distribution inside the cells. The chemical properties of boron and the need to discriminate different isotopes make the investigation of the concentration and distribution of 10B a challenging task. The most advanced techniques to measure and image boron are described, both invasive and non-invasive. The most promising approach for further investigation will be the complementary use of the different techniques to obtain the information that is mandatory for the future of this innovative treatment modality.
KW - Electron Energy Loss Spectroscopy
KW - Inductively Coupled Plasma Mass Spectroscopy
KW - Ion Trap Mass Spectrometry
KW - laser-SNMS
KW - Neutron Capture Radiography
KW - Nuclear Magnetic Resonance
KW - Positron Emission Tomography
KW - Prompt Gamma-ray Spectroscopy
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U2 - 10.1016/j.critrevonc.2008.03.004
DO - 10.1016/j.critrevonc.2008.03.004
M3 - Review article
C2 - 18439836
AN - SCOPUS:50449087145
SN - 1040-8428
VL - 68
SP - 66
EP - 90
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
IS - 1
ER -
