[Botulism: structure and function of botulinum toxin and its clinical application].

Keiji Oguma, Yumiko Yamamoto, Tomonori Suzuki, Ni Nengah Dwi Fatmawati, Kumiko Fujita

Research output: Contribution to journalReview articlepeer-review


Clostridium botulinum produces seven immunological distinct poisonous neurotoxins, A to G, with molecular masses of approximately 150kDa. In acidic foods and culture fluid, the neurotoxins associate with non-toxic components, and form large complexes designated progenitor toxins. The progenitor toxins are found in three forms named LL, L, and M. These neurotoxins and progenitor toxins were purified, and whole nucleotide sequences of their structure genes were determined. In this manuscript, the structure and function of these toxins, and the application of these toxins to clinical usage have been described.

Original languageEnglish
Pages (from-to)1329-1337
Number of pages9
JournalNihon rinsho. Japanese journal of clinical medicine
Issue number8
Publication statusPublished - Aug 2012
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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