TY - JOUR
T1 - [Botulism
T2 - structure and function of botulinum toxin and its clinical application].
AU - Oguma, Keiji
AU - Yamamoto, Yumiko
AU - Suzuki, Tomonori
AU - Fatmawati, Ni Nengah Dwi
AU - Fujita, Kumiko
PY - 2012/8
Y1 - 2012/8
N2 - Clostridium botulinum produces seven immunological distinct poisonous neurotoxins, A to G, with molecular masses of approximately 150kDa. In acidic foods and culture fluid, the neurotoxins associate with non-toxic components, and form large complexes designated progenitor toxins. The progenitor toxins are found in three forms named LL, L, and M. These neurotoxins and progenitor toxins were purified, and whole nucleotide sequences of their structure genes were determined. In this manuscript, the structure and function of these toxins, and the application of these toxins to clinical usage have been described.
AB - Clostridium botulinum produces seven immunological distinct poisonous neurotoxins, A to G, with molecular masses of approximately 150kDa. In acidic foods and culture fluid, the neurotoxins associate with non-toxic components, and form large complexes designated progenitor toxins. The progenitor toxins are found in three forms named LL, L, and M. These neurotoxins and progenitor toxins were purified, and whole nucleotide sequences of their structure genes were determined. In this manuscript, the structure and function of these toxins, and the application of these toxins to clinical usage have been described.
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M3 - Review article
C2 - 22894067
AN - SCOPUS:84872052053
SN - 0047-1852
VL - 70
SP - 1329
EP - 1337
JO - Nihon rinsho. Japanese journal of clinical medicine
JF - Nihon rinsho. Japanese journal of clinical medicine
IS - 8
ER -