Bovine trabecular cells produce TIMP-1 and MMP-2 in response to mechanical stretching

Yumiko Okada, Toshihiko Matsuo, Hiroshi Ohtsuki

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)


Bovine trabecular cells in growth phase were exposed to cyclic mechanical stretching of the bottom of a culture dish at a cycle of 30 seconds for 72 hours. The stretched cells produced significantly larger amounts of metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-1 (TIMP-1) after 72 hours, compared with cells in nonstretched control. In contrast, TIMP-2 and MMP-9 levels were not influenced by mechanical stretching. Trabecular cells would modify extracellular matrix in response to such mechanical stimuli as bending of trabecular meshwork or aqueous flow by the production of TIMP-1 and MMP-2.

Original languageEnglish
Pages (from-to)90-94
Number of pages5
JournalJapanese Journal of Ophthalmology
Issue number2
Publication statusPublished - Mar 1998


  • Cyclic mechanical stretching
  • Matrix metalloproteinase-2 and 9 (MMP-2 and MMP-9)
  • Tissue inhibitor of metalloproteinase-1 and 2 (TIMP-1 and TIMP-2)
  • Trabecular cells

ASJC Scopus subject areas

  • Ophthalmology


Dive into the research topics of 'Bovine trabecular cells produce TIMP-1 and MMP-2 in response to mechanical stretching'. Together they form a unique fingerprint.

Cite this