Brachial artery diameter as a marker for cardiovascular risk assessment: FMD-J study

Tatsuya Maruhashi; Junko Soga; Noritaka Fujimura; Naomi Idei; Shinsuke Mikami; Yumiko Iwamoto; Akimichi Iwamoto; Masato Kajikawa; Takeshi Matsumoto; Nozomu Oda; Shinji Kishimoto; Shogo Matsui; Haruki Hashimoto; Yoshiki Aibara; Farina Mohamad Yusoff; Takayuki Hidaka; Yasuki Kihara; Kazuaki Chayama; Kensuke Noma; Ayumu Nakashima; Chikara Goto; Hirofumi Tomiyama; Bonpei Takase; Takahide Kohro; Toru Suzuki; Tomoko Ishizu; Shinichiro Ueda; Tsutomu Yamazaki; Tomoo Furumoto; Kazuomi Kario; Teruo Inoue; Shinji Koba; Kentaro Watanabe; Yasuhiko Takemoto; Takuzo Hano; Masataka Sata; Yutaka Ishibashi; Koichi Node; Koji Maemura; Yusuke Ohya; Taiji Furukawa; Hiroshi Ito; Hisao Ikeda; Akira Yamashina; Yukihito Higashi

doi:10.1016/j.atherosclerosis.2017.11.022

Brachial artery diameter as a marker for cardiovascular risk assessment: FMD-J study

Tatsuya Maruhashi, Junko Soga, Noritaka Fujimura, Naomi Idei, Shinsuke Mikami, Yumiko Iwamoto, Akimichi Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Nozomu Oda, Shinji Kishimoto, Shogo Matsui, Haruki Hashimoto, Yoshiki Aibara, Farina Mohamad Yusoff, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Kensuke Noma, Ayumu NakashimaChikara Goto, Hirofumi Tomiyama, Bonpei Takase, Takahide Kohro, Toru Suzuki, Tomoko Ishizu, Shinichiro Ueda, Tsutomu Yamazaki, Tomoo Furumoto, Kazuomi Kario, Teruo Inoue, Shinji Koba, Kentaro Watanabe, Yasuhiko Takemoto, Takuzo Hano, Masataka Sata, Yutaka Ishibashi, Koichi Node, Koji Maemura, Yusuke Ohya, Taiji Furukawa, Hiroshi Ito, Hisao Ikeda, Akira Yamashina, Yukihito Higashi

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Background and aims Baseline brachial artery (BBA) diameter has been reported to be a potential confounding factor of flow-mediated vasodilation (FMD). The purpose of this study was to evaluate the relationships between BBA diameter and cardiovascular risk factors and compare the diagnostic accuracy of BBA diameter in subjects without cardiovascular risk factors and patients with cardiovascular disease (CVD) with that of FMD. Methods We measured BBA diameter and FMD in 5695 male subjects. In addition, we retrospectively investigated the incidence of cardiovascular events using another population sample consisting of 440 male subjects, to compare the accuracy of BBA diameter with that of FMD in predicting cardiovascular events. Results BBA diameter and FMD significantly correlated with age, body mass index, systolic blood pressure, diastolic blood pressure, triglycerides, high-density lipoprotein cholesterol, and glucose as well as Framingham risk score. The prevalence of cardiovascular risk factors and CVD increased with the increase in BBA diameter and FMD. Area under the curve (AUC) value of the receiver operating characteristic (ROC) curve for BBA diameter to diagnose subjects without cardiovascular risk factors (0.59 vs. 0.62, p = 0.001) or patients with CVD (0.58 vs. 0.64, p < 0.001) was significantly lower than that for FMD. In the retrospective study, the AUC value of the ROC curve for BBA diameter to predict first major cardiovascular events was significantly lower than that of FMD (0.50 vs. 0.62, p = 0.03). Conclusions In men, BBA diameter was inferior to FMD for assessment of cardiovascular risk.

Original language	English
Pages (from-to)	92-98
Number of pages	7
Journal	Atherosclerosis
Volume	268
DOIs	https://doi.org/10.1016/j.atherosclerosis.2017.11.022
Publication status	Published - Jan 2018

Keywords

Atherosclerosis
Baseline brachial artery diameter
Cardiovascular risk factor
Flow-mediated vasodilation

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.atherosclerosis.2017.11.022

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Maruhashi, T., Soga, J., Fujimura, N., Idei, N., Mikami, S., Iwamoto, Y., Iwamoto, A., Kajikawa, M., Matsumoto, T., Oda, N., Kishimoto, S., Matsui, S., Hashimoto, H., Aibara, Y., Yusoff, F. M., Hidaka, T., Kihara, Y., Chayama, K., Noma, K., ... Higashi, Y. (2018). Brachial artery diameter as a marker for cardiovascular risk assessment: FMD-J study. Atherosclerosis, 268, 92-98. https://doi.org/10.1016/j.atherosclerosis.2017.11.022

Maruhashi, T, Soga, J, Fujimura, N, Idei, N, Mikami, S, Iwamoto, Y, Iwamoto, A, Kajikawa, M, Matsumoto, T, Oda, N, Kishimoto, S, Matsui, S, Hashimoto, H, Aibara, Y, Yusoff, FM, Hidaka, T, Kihara, Y, Chayama, K, Noma, K, Nakashima, A, Goto, C, Tomiyama, H, Takase, B, Kohro, T, Suzuki, T, Ishizu, T, Ueda, S, Yamazaki, T, Furumoto, T, Kario, K, Inoue, T, Koba, S, Watanabe, K, Takemoto, Y, Hano, T, Sata, M, Ishibashi, Y, Node, K, Maemura, K, Ohya, Y, Furukawa, T, Ito, H, Ikeda, H, Yamashina, A & Higashi, Y 2018, 'Brachial artery diameter as a marker for cardiovascular risk assessment: FMD-J study', Atherosclerosis, vol. 268, pp. 92-98. https://doi.org/10.1016/j.atherosclerosis.2017.11.022

@article{65c3f94c550a4b01bb5d397c4e736201,

title = "Brachial artery diameter as a marker for cardiovascular risk assessment: FMD-J study",

abstract = "Background and aims Baseline brachial artery (BBA) diameter has been reported to be a potential confounding factor of flow-mediated vasodilation (FMD). The purpose of this study was to evaluate the relationships between BBA diameter and cardiovascular risk factors and compare the diagnostic accuracy of BBA diameter in subjects without cardiovascular risk factors and patients with cardiovascular disease (CVD) with that of FMD. Methods We measured BBA diameter and FMD in 5695 male subjects. In addition, we retrospectively investigated the incidence of cardiovascular events using another population sample consisting of 440 male subjects, to compare the accuracy of BBA diameter with that of FMD in predicting cardiovascular events. Results BBA diameter and FMD significantly correlated with age, body mass index, systolic blood pressure, diastolic blood pressure, triglycerides, high-density lipoprotein cholesterol, and glucose as well as Framingham risk score. The prevalence of cardiovascular risk factors and CVD increased with the increase in BBA diameter and FMD. Area under the curve (AUC) value of the receiver operating characteristic (ROC) curve for BBA diameter to diagnose subjects without cardiovascular risk factors (0.59 vs. 0.62, p = 0.001) or patients with CVD (0.58 vs. 0.64, p < 0.001) was significantly lower than that for FMD. In the retrospective study, the AUC value of the ROC curve for BBA diameter to predict first major cardiovascular events was significantly lower than that of FMD (0.50 vs. 0.62, p = 0.03). Conclusions In men, BBA diameter was inferior to FMD for assessment of cardiovascular risk.",

keywords = "Atherosclerosis, Baseline brachial artery diameter, Cardiovascular risk factor, Flow-mediated vasodilation",

author = "Tatsuya Maruhashi and Junko Soga and Noritaka Fujimura and Naomi Idei and Shinsuke Mikami and Yumiko Iwamoto and Akimichi Iwamoto and Masato Kajikawa and Takeshi Matsumoto and Nozomu Oda and Shinji Kishimoto and Shogo Matsui and Haruki Hashimoto and Yoshiki Aibara and Yusoff, {Farina Mohamad} and Takayuki Hidaka and Yasuki Kihara and Kazuaki Chayama and Kensuke Noma and Ayumu Nakashima and Chikara Goto and Hirofumi Tomiyama and Bonpei Takase and Takahide Kohro and Toru Suzuki and Tomoko Ishizu and Shinichiro Ueda and Tsutomu Yamazaki and Tomoo Furumoto and Kazuomi Kario and Teruo Inoue and Shinji Koba and Kentaro Watanabe and Yasuhiko Takemoto and Takuzo Hano and Masataka Sata and Yutaka Ishibashi and Koichi Node and Koji Maemura and Yusuke Ohya and Taiji Furukawa and Hiroshi Ito and Hisao Ikeda and Akira Yamashina and Yukihito Higashi",

note = "Funding Information: This study was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan ( 18590815 and 21590898 ) and a Grant in Aid of Japanese Arteriosclerosis Prevention Fund . Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2018",

month = jan,

doi = "10.1016/j.atherosclerosis.2017.11.022",

language = "English",

volume = "268",

pages = "92--98",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Brachial artery diameter as a marker for cardiovascular risk assessment

T2 - FMD-J study

AU - Maruhashi, Tatsuya

AU - Soga, Junko

AU - Fujimura, Noritaka

AU - Idei, Naomi

AU - Mikami, Shinsuke

AU - Iwamoto, Yumiko

AU - Iwamoto, Akimichi

AU - Kajikawa, Masato

AU - Matsumoto, Takeshi

AU - Oda, Nozomu

AU - Kishimoto, Shinji

AU - Matsui, Shogo

AU - Hashimoto, Haruki

AU - Aibara, Yoshiki

AU - Yusoff, Farina Mohamad

AU - Hidaka, Takayuki

AU - Kihara, Yasuki

AU - Chayama, Kazuaki

AU - Noma, Kensuke

AU - Nakashima, Ayumu

AU - Goto, Chikara

AU - Tomiyama, Hirofumi

AU - Takase, Bonpei

AU - Kohro, Takahide

AU - Suzuki, Toru

AU - Ishizu, Tomoko

AU - Ueda, Shinichiro

AU - Yamazaki, Tsutomu

AU - Furumoto, Tomoo

AU - Kario, Kazuomi

AU - Inoue, Teruo

AU - Koba, Shinji

AU - Watanabe, Kentaro

AU - Takemoto, Yasuhiko

AU - Hano, Takuzo

AU - Sata, Masataka

AU - Ishibashi, Yutaka

AU - Node, Koichi

AU - Maemura, Koji

AU - Ohya, Yusuke

AU - Furukawa, Taiji

AU - Ito, Hiroshi

AU - Ikeda, Hisao

AU - Yamashina, Akira

AU - Higashi, Yukihito

N1 - Funding Information: This study was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan ( 18590815 and 21590898 ) and a Grant in Aid of Japanese Arteriosclerosis Prevention Fund . Publisher Copyright: © 2017 Elsevier B.V.

PY - 2018/1

Y1 - 2018/1

N2 - Background and aims Baseline brachial artery (BBA) diameter has been reported to be a potential confounding factor of flow-mediated vasodilation (FMD). The purpose of this study was to evaluate the relationships between BBA diameter and cardiovascular risk factors and compare the diagnostic accuracy of BBA diameter in subjects without cardiovascular risk factors and patients with cardiovascular disease (CVD) with that of FMD. Methods We measured BBA diameter and FMD in 5695 male subjects. In addition, we retrospectively investigated the incidence of cardiovascular events using another population sample consisting of 440 male subjects, to compare the accuracy of BBA diameter with that of FMD in predicting cardiovascular events. Results BBA diameter and FMD significantly correlated with age, body mass index, systolic blood pressure, diastolic blood pressure, triglycerides, high-density lipoprotein cholesterol, and glucose as well as Framingham risk score. The prevalence of cardiovascular risk factors and CVD increased with the increase in BBA diameter and FMD. Area under the curve (AUC) value of the receiver operating characteristic (ROC) curve for BBA diameter to diagnose subjects without cardiovascular risk factors (0.59 vs. 0.62, p = 0.001) or patients with CVD (0.58 vs. 0.64, p < 0.001) was significantly lower than that for FMD. In the retrospective study, the AUC value of the ROC curve for BBA diameter to predict first major cardiovascular events was significantly lower than that of FMD (0.50 vs. 0.62, p = 0.03). Conclusions In men, BBA diameter was inferior to FMD for assessment of cardiovascular risk.

AB - Background and aims Baseline brachial artery (BBA) diameter has been reported to be a potential confounding factor of flow-mediated vasodilation (FMD). The purpose of this study was to evaluate the relationships between BBA diameter and cardiovascular risk factors and compare the diagnostic accuracy of BBA diameter in subjects without cardiovascular risk factors and patients with cardiovascular disease (CVD) with that of FMD. Methods We measured BBA diameter and FMD in 5695 male subjects. In addition, we retrospectively investigated the incidence of cardiovascular events using another population sample consisting of 440 male subjects, to compare the accuracy of BBA diameter with that of FMD in predicting cardiovascular events. Results BBA diameter and FMD significantly correlated with age, body mass index, systolic blood pressure, diastolic blood pressure, triglycerides, high-density lipoprotein cholesterol, and glucose as well as Framingham risk score. The prevalence of cardiovascular risk factors and CVD increased with the increase in BBA diameter and FMD. Area under the curve (AUC) value of the receiver operating characteristic (ROC) curve for BBA diameter to diagnose subjects without cardiovascular risk factors (0.59 vs. 0.62, p = 0.001) or patients with CVD (0.58 vs. 0.64, p < 0.001) was significantly lower than that for FMD. In the retrospective study, the AUC value of the ROC curve for BBA diameter to predict first major cardiovascular events was significantly lower than that of FMD (0.50 vs. 0.62, p = 0.03). Conclusions In men, BBA diameter was inferior to FMD for assessment of cardiovascular risk.

KW - Atherosclerosis

KW - Baseline brachial artery diameter

KW - Cardiovascular risk factor

KW - Flow-mediated vasodilation

UR - http://www.scopus.com/inward/record.url?scp=85035801160&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85035801160&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2017.11.022

DO - 10.1016/j.atherosclerosis.2017.11.022

M3 - Article

C2 - 29195110

AN - SCOPUS:85035801160

SN - 0021-9150

VL - 268

SP - 92

EP - 98

JO - Atherosclerosis

JF - Atherosclerosis

ER -

Brachial artery diameter as a marker for cardiovascular risk assessment: FMD-J study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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