Brain link proteins: New insights for hyaluronan-binding proteoglycans in brain

Toshitaka Oohashi, Yoshifumi Ninomiya

Research output: Contribution to journalReview articlepeer-review


Link protein is originally characterized as an abundant extracellular matrix protein in cartilage and named Crt11. It can stabilize aggregates of aggrecan and hyaluronan, giving cartilage its tensile strength. Similarly to the cartilage matrix, a high content of hyaluronan matrix has also been recognized in the brain matrix. Subsequently, several hyaluronan binding chondroitin sulphate proteoglycans, called lecticans, have been identified as the abundant extracellular matrix molecules in the developing and/or adult brain. Other than Crt11, brain-specific link protein gene, Bra11, was cloned recently. The two link proteins (LPs), old and new, are differentially expressed and seemed to be coordinately expressed with lecticans in the brain. In this review, we will focus on these brain link proteins that may play crucial roles in hyaluronan matrix.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalConnective Tissue
Issue number1
Publication statusPublished - Mar 2003


  • Brain
  • Hyaluronan
  • Lectican/hyalectan
  • Link protein
  • Nodes of Ranvier
  • Proteoglycan

ASJC Scopus subject areas

  • Rheumatology


Dive into the research topics of 'Brain link proteins: New insights for hyaluronan-binding proteoglycans in brain'. Together they form a unique fingerprint.

Cite this