TY - JOUR
T1 - Brain regional uptake of radioactive Sc, Mn, Zn, Se, Rb and Zr tracers into normal mice during aging
AU - Amano, R.
AU - Enomoto, S.
N1 - Funding Information:
The authors are grateful for the cooperation of all the staff members of the RIKEN Ring Cyclotron and the other members of the multitracer group at RIKEN. The present work was partially supported by a Grant-in-Aid for Scientific Research (07640742 and 10640539) of the Ministry of Education, Science, Sports and Culture of Japan.
PY - 2001
Y1 - 2001
N2 - Radioactive multitracer technique was applied to study the brain regional uptake of trace elements by the normal mice during aging. The brain regional radioactivities of 46Sc, 54Mn, 65Zn, 75Se, 83Rb and 88Zr were measured 48 hours after intraperitoneal injection of a solution in normal mice aged 6 to 52 weeks to evaluate the brain regional (corpus striatum, cerebellum, cerebral cortex, hippocampus, and pons and medulla) uptakes. The radioactive distributions of 46Sc, 54Mn and 88Zr tracers were variable and region-specific in the brain, while those of 65Zn, 75Se and 83Rb tracers were comparable among all regions of interest. The brain regional uptakes of all tracers slightly increased with age from 10 to 28 weeks, and then remained constant during aging after 28 weeks. These uptake variations may be involved in the functional degenerative process of the blood-brain barrier during aging.
AB - Radioactive multitracer technique was applied to study the brain regional uptake of trace elements by the normal mice during aging. The brain regional radioactivities of 46Sc, 54Mn, 65Zn, 75Se, 83Rb and 88Zr were measured 48 hours after intraperitoneal injection of a solution in normal mice aged 6 to 52 weeks to evaluate the brain regional (corpus striatum, cerebellum, cerebral cortex, hippocampus, and pons and medulla) uptakes. The radioactive distributions of 46Sc, 54Mn and 88Zr tracers were variable and region-specific in the brain, while those of 65Zn, 75Se and 83Rb tracers were comparable among all regions of interest. The brain regional uptakes of all tracers slightly increased with age from 10 to 28 weeks, and then remained constant during aging after 28 weeks. These uptake variations may be involved in the functional degenerative process of the blood-brain barrier during aging.
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U2 - 10.1023/A:1010666007541
DO - 10.1023/A:1010666007541
M3 - Article
AN - SCOPUS:0035109158
SN - 0022-4081
VL - 247
SP - 507
EP - 511
JO - Journal of Radioanalytical Chemistry
JF - Journal of Radioanalytical Chemistry
IS - 3
ER -
