Brown adipose tissue: Evaluation with 201Tl and 99mTc-sestamibi dual-tracer SPECT

Takahiro Higuchi, Seigo Kinuya, Junichi Taki, Kenichi Nakajima, Masatoshi Ikeda, Masanobu Namura, Norihisa Tonami

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Brown adipose tissue is one kind of adipose tissue and regulates body temperature and balance of energy via non-shivering thermogenesis. The authors present a case that strongly suggested the presence of activated brown adipose tissue in the neck, shoulders and axillary space by increased 18F-FDG uptake. 99mTc-sestamibi and 201Tl dual-tracer SPECT study showed increased 99mTc-sestamibi uptake and non-increased 201Tl uptake in the corresponding 18F-FDG uptake sites. Brown adipose tissue has dense mitochondria in the cells, which play an important role in thermogenesis. 99mTc-sestamibi uptake and retention depend on the mitochondrial activity but 201Tl uptake does not. Therefore, the activity of mitochondria in activated brown adipose tissue may explain the discrepant uptake between 99mTc-sestamibi and 201Tl.

Original languageEnglish
Pages (from-to)547-549
Number of pages3
JournalAnnals of nuclear medicine
Issue number6
Publication statusPublished - Sept 2004
Externally publishedYes


  • Brown adipose tissue
  • PET

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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