Buspirone enhances head twitch behavior in mice

Yoshihisa Kitamura; Tadashi Nagatani; Takami Watanabe

doi:10.1016/0014-2999(94)90206-2

Buspirone enhances head twitch behavior in mice

Yoshihisa Kitamura, Tadashi Nagatani, Takami Watanabe

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We studied the effects of buspirone, a 5-HT_1A receptor agonist, on head twitch behavior induced by 5-hydroxy-l-tryptophan (5-HTP) administered together with pargyline in mice. Buspirone dose dependently (0.1 - 10 mg/kg i.p.) enhanced head twitch behavior. This effect was blocked by (-)-propranolol and NAN-190 (1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]-piperazine hydrobromide). The enhancing effect of buspirone was also observed when mice were pretreated with p-chlorophenylalanine. These findings suggest that the enhancing effect of buspirone on head twitch behavior may be extended through the activation of post-synaptic 5-HT_1A receptors.

Original language	English
Pages (from-to)	297-301
Number of pages	5
Journal	European Journal of Pharmacology
Volume	253
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(94)90206-2
Publication status	Published - Mar 3 1994
Externally published	Yes

Keywords

(8-hydroxy-2-(di-n-propylamino)tetralin)
(Mouse)
5-HT receptor
5-HT receptors
8-OH-DPAT
Buspirone
Head twitch behavior

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(94)90206-2

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title = "Buspirone enhances head twitch behavior in mice",

abstract = "We studied the effects of buspirone, a 5-HT1A receptor agonist, on head twitch behavior induced by 5-hydroxy-l-tryptophan (5-HTP) administered together with pargyline in mice. Buspirone dose dependently (0.1 - 10 mg/kg i.p.) enhanced head twitch behavior. This effect was blocked by (-)-propranolol and NAN-190 (1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]-piperazine hydrobromide). The enhancing effect of buspirone was also observed when mice were pretreated with p-chlorophenylalanine. These findings suggest that the enhancing effect of buspirone on head twitch behavior may be extended through the activation of post-synaptic 5-HT1A receptors.",

keywords = "(8-hydroxy-2-(di-n-propylamino)tetralin), (Mouse), 5-HT receptor, 5-HT receptors, 8-OH-DPAT, Buspirone, Head twitch behavior",

author = "Yoshihisa Kitamura and Tadashi Nagatani and Takami Watanabe",

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doi = "10.1016/0014-2999(94)90206-2",

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T1 - Buspirone enhances head twitch behavior in mice

AU - Kitamura, Yoshihisa

AU - Nagatani, Tadashi

AU - Watanabe, Takami

PY - 1994/3/3

Y1 - 1994/3/3

N2 - We studied the effects of buspirone, a 5-HT1A receptor agonist, on head twitch behavior induced by 5-hydroxy-l-tryptophan (5-HTP) administered together with pargyline in mice. Buspirone dose dependently (0.1 - 10 mg/kg i.p.) enhanced head twitch behavior. This effect was blocked by (-)-propranolol and NAN-190 (1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]-piperazine hydrobromide). The enhancing effect of buspirone was also observed when mice were pretreated with p-chlorophenylalanine. These findings suggest that the enhancing effect of buspirone on head twitch behavior may be extended through the activation of post-synaptic 5-HT1A receptors.

AB - We studied the effects of buspirone, a 5-HT1A receptor agonist, on head twitch behavior induced by 5-hydroxy-l-tryptophan (5-HTP) administered together with pargyline in mice. Buspirone dose dependently (0.1 - 10 mg/kg i.p.) enhanced head twitch behavior. This effect was blocked by (-)-propranolol and NAN-190 (1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]-piperazine hydrobromide). The enhancing effect of buspirone was also observed when mice were pretreated with p-chlorophenylalanine. These findings suggest that the enhancing effect of buspirone on head twitch behavior may be extended through the activation of post-synaptic 5-HT1A receptors.

KW - (8-hydroxy-2-(di-n-propylamino)tetralin)

KW - (Mouse)

KW - 5-HT receptor

KW - 5-HT receptors

KW - 8-OH-DPAT

KW - Buspirone

KW - Head twitch behavior

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JO - European Journal of Pharmacology

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IS - 3

ER -

Buspirone enhances head twitch behavior in mice

Abstract

Keywords

ASJC Scopus subject areas

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