Calcium-binding protein-immunoreactive innervation of the rat vibrissa

H. Ichikawa; T. Sugimoto

doi:10.1016/S0006-8993(03)02292-3

Calcium-binding protein-immunoreactive innervation of the rat vibrissa

H. Ichikawa, T. Sugimoto

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Immunohistochemistry detected calcium-binding proteins (CaBPs) in corpuscular and Merkel nerve endings of the rat vibrissa. CaBP-immunoreactive (ir) corpuscular endings were divided into two types: ramified and unramified endings. Ramified endings were subdivided into reticular and Ruffini endings. Unramified endings were identical to longitudinal lanceolate endings which have been described previously. Reticular and unramified endings as well as Merkel endings co-expressed neurocalcin (NC)- and parvalbumin (PV)-immunoreactivity (ir). However, such endings were devoid of peptide 19 (PEP19)-ir. PV-ir Ruffini endings were immunoreactive for PEP19 but not NC. The retrograde tracing method revealed that 34, 21 and 18% of trigeminal neurons which project to the infraorbital nerve exhibited NC-, PEP19- and PV-ir, respectively. In addition, 73 and 36% of the PV-ir neurons showed NC- and PEP19-ir, respectively. The content and co-expression of CaBPs in vibrissal low-threshold mechanoreceptors may depend on their terminal morphology.

Original language	English
Pages (from-to)	226-231
Number of pages	6
Journal	Brain Research
Volume	970
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(03)02292-3
Publication status	Published - Apr 25 2003

Keywords

Immunohistochemistry
Neurocalcin
Parvalbumin
Peptide 19
Trigeminal ganglion
Vibrissa

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/S0006-8993(03)02292-3

Cite this

@article{7e86a01dabf7405cb4d46b9b8c9a452a,

title = "Calcium-binding protein-immunoreactive innervation of the rat vibrissa",

abstract = "Immunohistochemistry detected calcium-binding proteins (CaBPs) in corpuscular and Merkel nerve endings of the rat vibrissa. CaBP-immunoreactive (ir) corpuscular endings were divided into two types: ramified and unramified endings. Ramified endings were subdivided into reticular and Ruffini endings. Unramified endings were identical to longitudinal lanceolate endings which have been described previously. Reticular and unramified endings as well as Merkel endings co-expressed neurocalcin (NC)- and parvalbumin (PV)-immunoreactivity (ir). However, such endings were devoid of peptide 19 (PEP19)-ir. PV-ir Ruffini endings were immunoreactive for PEP19 but not NC. The retrograde tracing method revealed that 34, 21 and 18% of trigeminal neurons which project to the infraorbital nerve exhibited NC-, PEP19- and PV-ir, respectively. In addition, 73 and 36% of the PV-ir neurons showed NC- and PEP19-ir, respectively. The content and co-expression of CaBPs in vibrissal low-threshold mechanoreceptors may depend on their terminal morphology.",

keywords = "Immunohistochemistry, Neurocalcin, Parvalbumin, Peptide 19, Trigeminal ganglion, Vibrissa",

author = "H. Ichikawa and T. Sugimoto",

note = "Funding Information: We greatly appreciate Dr James I. Morgan at the Department of Developmental Neurobiology, St. Jude Children{\textquoteright}s Research Hospital and Dr. Hiroyoshi Hidaka at the Department of Pharmacology, Nagoya University School of Medicine for their kind gift of the antisera to PEP19 and NC, respectively. This work was supported by a grant from the Japanese Ministry of Education, Culture, Sports, Science and Technology to H.I. (No. 14571733).",

year = "2003",

month = apr,

day = "25",

doi = "10.1016/S0006-8993(03)02292-3",

language = "English",

volume = "970",

pages = "226--231",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Calcium-binding protein-immunoreactive innervation of the rat vibrissa

AU - Ichikawa, H.

AU - Sugimoto, T.

N1 - Funding Information: We greatly appreciate Dr James I. Morgan at the Department of Developmental Neurobiology, St. Jude Children’s Research Hospital and Dr. Hiroyoshi Hidaka at the Department of Pharmacology, Nagoya University School of Medicine for their kind gift of the antisera to PEP19 and NC, respectively. This work was supported by a grant from the Japanese Ministry of Education, Culture, Sports, Science and Technology to H.I. (No. 14571733).

PY - 2003/4/25

Y1 - 2003/4/25

N2 - Immunohistochemistry detected calcium-binding proteins (CaBPs) in corpuscular and Merkel nerve endings of the rat vibrissa. CaBP-immunoreactive (ir) corpuscular endings were divided into two types: ramified and unramified endings. Ramified endings were subdivided into reticular and Ruffini endings. Unramified endings were identical to longitudinal lanceolate endings which have been described previously. Reticular and unramified endings as well as Merkel endings co-expressed neurocalcin (NC)- and parvalbumin (PV)-immunoreactivity (ir). However, such endings were devoid of peptide 19 (PEP19)-ir. PV-ir Ruffini endings were immunoreactive for PEP19 but not NC. The retrograde tracing method revealed that 34, 21 and 18% of trigeminal neurons which project to the infraorbital nerve exhibited NC-, PEP19- and PV-ir, respectively. In addition, 73 and 36% of the PV-ir neurons showed NC- and PEP19-ir, respectively. The content and co-expression of CaBPs in vibrissal low-threshold mechanoreceptors may depend on their terminal morphology.

AB - Immunohistochemistry detected calcium-binding proteins (CaBPs) in corpuscular and Merkel nerve endings of the rat vibrissa. CaBP-immunoreactive (ir) corpuscular endings were divided into two types: ramified and unramified endings. Ramified endings were subdivided into reticular and Ruffini endings. Unramified endings were identical to longitudinal lanceolate endings which have been described previously. Reticular and unramified endings as well as Merkel endings co-expressed neurocalcin (NC)- and parvalbumin (PV)-immunoreactivity (ir). However, such endings were devoid of peptide 19 (PEP19)-ir. PV-ir Ruffini endings were immunoreactive for PEP19 but not NC. The retrograde tracing method revealed that 34, 21 and 18% of trigeminal neurons which project to the infraorbital nerve exhibited NC-, PEP19- and PV-ir, respectively. In addition, 73 and 36% of the PV-ir neurons showed NC- and PEP19-ir, respectively. The content and co-expression of CaBPs in vibrissal low-threshold mechanoreceptors may depend on their terminal morphology.

KW - Immunohistochemistry

KW - Neurocalcin

KW - Parvalbumin

KW - Peptide 19

KW - Trigeminal ganglion

KW - Vibrissa

UR - http://www.scopus.com/inward/record.url?scp=0037466344&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037466344&partnerID=8YFLogxK

U2 - 10.1016/S0006-8993(03)02292-3

DO - 10.1016/S0006-8993(03)02292-3

M3 - Article

C2 - 12706265

AN - SCOPUS:0037466344

SN - 0006-8993

VL - 970

SP - 226

EP - 231

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Calcium-binding protein-immunoreactive innervation of the rat vibrissa

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this