TY - JOUR
T1 - Campylobacter rectus in the Oral Cavity Correlates with Proteinuria in Immunoglobulin A Nephropathy Patients
AU - Misaki, Taro
AU - Naka, Shuhei
AU - Wato, Kaoruko
AU - Hatakeyama, Rina
AU - Nagasawa, Yasuyuki
AU - Ito, Seigo
AU - Inaba, Hiroaki
AU - Nomura, Ryota
AU - Matsumoto-Nakano, Michiyo
AU - Nakano, Kazuhiko
N1 - Funding Information:
This work was supported by JSPS KAKENHI Grant Number 15K15754. We appreciate the assistance of Prof. Howard K. Kuramitsu (State University of New York at Buffalo) in the preparation of this manuscript and Dr. Yoichiro Homma (Seirei Hamamatsu General Hospital) for assistance with statistical analysis.
Publisher Copyright:
© 2018 S. Karger AG, Basel.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Background: Periodontitis-related pathogens, such as Campylobacter or Treponema species, have recently been shown to be associated with immunoglobulin A nephropathy (IgAN). Some strains of Streptococcus mutans, a major pathogen of dental caries, harbour the cnm gene that encodes a collagen-binding protein (Cnm). This has also been demonstrated to be associated with urinary protein levels in IgAN patients. Objectives: The purpose of the present study was to analyse the association of IgAN with C. rectus, Treponema denticola and cnm-positive S. mutans in the oral cavity of humans. Methods: The presence of C. rectus, T. denticola and cnm-positive S. mutans strains in saliva samples of 117 IgAN patients and 56 healthy controls was evaluated by PCR, and the subjects' clinical parameters were analysed. Results: C. rectus was significantly more prevalent in the IgAN group than in the control group (p < 0.05). The C. rectus-positive group was significantly associated with proteinuria in the IgAN group (p < 0.05). In addition, the C. rectus-positive and cnm-positive S. mutans group was shown to be more closely associated with urinary protein levels than the other groups (p < 0.0083). Conclusion: Our results suggest that harbouring C. rectus in the oral cavity could be associated with proteinuria in IgAN patients.
AB - Background: Periodontitis-related pathogens, such as Campylobacter or Treponema species, have recently been shown to be associated with immunoglobulin A nephropathy (IgAN). Some strains of Streptococcus mutans, a major pathogen of dental caries, harbour the cnm gene that encodes a collagen-binding protein (Cnm). This has also been demonstrated to be associated with urinary protein levels in IgAN patients. Objectives: The purpose of the present study was to analyse the association of IgAN with C. rectus, Treponema denticola and cnm-positive S. mutans in the oral cavity of humans. Methods: The presence of C. rectus, T. denticola and cnm-positive S. mutans strains in saliva samples of 117 IgAN patients and 56 healthy controls was evaluated by PCR, and the subjects' clinical parameters were analysed. Results: C. rectus was significantly more prevalent in the IgAN group than in the control group (p < 0.05). The C. rectus-positive group was significantly associated with proteinuria in the IgAN group (p < 0.05). In addition, the C. rectus-positive and cnm-positive S. mutans group was shown to be more closely associated with urinary protein levels than the other groups (p < 0.0083). Conclusion: Our results suggest that harbouring C. rectus in the oral cavity could be associated with proteinuria in IgAN patients.
KW - Campylobacter rectus
KW - Cnm
KW - Immunoglobulin A nephropathy
KW - Streptococcus mutans
UR - http://www.scopus.com/inward/record.url?scp=85042076098&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042076098&partnerID=8YFLogxK
U2 - 10.1159/000487103
DO - 10.1159/000487103
M3 - Article
C2 - 29428934
AN - SCOPUS:85042076098
SN - 1660-8151
VL - 139
SP - 143
EP - 149
JO - Nephron
JF - Nephron
IS - 2
ER -