Cancer Stem Cells Contribute to Drug Resistance in Multiple Different Ways

Maram H. Zahra, Hend M. Nawara, Ghmkin Hassan, Said M. Afify, Akimasa Seno, Masaharu Seno

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Many tumors are resistant to conventional cancer therapies because a tumor is composed of heterogeneous cell population. Especially, subpopulation of cancer stem cells, which have self-renewal and differentiation properties and responsible for the tumor initiation, is generally considered resistant to chemo-, radio-, and immune therapy. Understanding the mechanism of drug resistance in cancer stem cells should lead to establish more effective therapeutic strategies. Actually, different molecular mechanisms are conceivable for cancer stem cells acquiring drug resistance. These mechanisms include not only cytoplasmic signaling pathways but also the intercellular communications in the tumor microenvironment. Recently, a great deal of successful reports challenged to elucidate the mechanisms of drug resistance and to develop novel treatments targeting cancer stem cells.

Original languageEnglish
Pages (from-to)125-139
Number of pages15
JournalAdvances in experimental medicine and biology
Publication statusPublished - 2022


  • Cancer stem cells
  • Drug resistance
  • Signal pathways
  • Treatments

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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