TY - JOUR
T1 - Cancer/testis antigens
T2 - A prospective reagent as diagnostic and immunotherapeutic targets for squamous cell carcinoma of the head and neck
AU - Domae, Shohei
AU - Ono, Toshiro
AU - Sasaki, Akira
N1 - Funding Information:
We thank Dr. Eiichi Nakayama at the Faculty of Health and Welfare, Kawasaki University of Medical Welfare for his continuous support during this study. This work was supported in part by a Grant-in Aid for Scientific Research (C) Grant Number 20590571 (T.O.), and Young Scientists (B) Grant Numbers 21791997 , 23792343 (S.D.) from the Japan Society for the Promotion of Science .
Publisher Copyright:
© 2014 Japanese Association for Dental Science.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Numerous tumor antigens have so far been identified from various tumors using the serological identification of antigens by recombinant expression cloning (SEREX) method. Among them, cancer/testis (CT) antigens are considered promising target molecules for immunotherapy for patients with various cancers. We performed several SEREX analyses of various cancers to identify CT antigens, including gastric adenocarcinoma, lung adenocarcinoma, and colon cancer, and consequently identified additional CT antigens, such as XAGE-1, CCDC62-2, GKAP1, and TEKT5. However, although SEREX analysis of squamous cell carcinoma of the head and neck (HNSCC) has been performed several times, only a few CT or HNSCC specific antigens have yet been isolated. Compared with other tumors, a small number of studies have been reported on the antigen proteins specific to HNSCC. We here reported the expression of selected CT antigens and their immunogenicity in patients with HNSCC. The results obtained suggested that CCDC62-2, GKAP1, and TEKT5 are immunogenic in HNSCC and also demonstrated their potencies as diagnostic markers for patients with HNSCC in combination with other CT antigens such as NY-ESO-1, MAGE-A3, and MAGE-A4.
AB - Numerous tumor antigens have so far been identified from various tumors using the serological identification of antigens by recombinant expression cloning (SEREX) method. Among them, cancer/testis (CT) antigens are considered promising target molecules for immunotherapy for patients with various cancers. We performed several SEREX analyses of various cancers to identify CT antigens, including gastric adenocarcinoma, lung adenocarcinoma, and colon cancer, and consequently identified additional CT antigens, such as XAGE-1, CCDC62-2, GKAP1, and TEKT5. However, although SEREX analysis of squamous cell carcinoma of the head and neck (HNSCC) has been performed several times, only a few CT or HNSCC specific antigens have yet been isolated. Compared with other tumors, a small number of studies have been reported on the antigen proteins specific to HNSCC. We here reported the expression of selected CT antigens and their immunogenicity in patients with HNSCC. The results obtained suggested that CCDC62-2, GKAP1, and TEKT5 are immunogenic in HNSCC and also demonstrated their potencies as diagnostic markers for patients with HNSCC in combination with other CT antigens such as NY-ESO-1, MAGE-A3, and MAGE-A4.
KW - Antibody response
KW - Cancer/testis antigen
KW - SEREX
KW - Squamous cell carcinoma of the head and neck
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U2 - 10.1016/j.jdsr.2014.06.001
DO - 10.1016/j.jdsr.2014.06.001
M3 - Review article
AN - SCOPUS:84908552807
SN - 1882-7616
VL - 50
SP - 91
EP - 99
JO - Dentistry in Japan
JF - Dentistry in Japan
IS - 4
ER -
