Carrier rate of Factor XI deficiency in stunted Japanese black cattle

Daisaku Watanabe, Takashi Hirano, Yoshikazu Sugimoto, Yoshimi Ogata, Shogo Abe, Takaaki Ando, Hiromichi Ohtsuka, Tetsuo Kunieda, Seiichi Kawamura

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10 Citations (Scopus)


Blood examinations and genotyping of Factor XI (F11) were performed in growth retardation Japanese Black cattle and their dams. Genotyping of F11 revealed that the recessive homozygous and heterozygous genotype frequencies were 5.2% and 50.0% in the Claudin-16 (CL-16) deficiency group (n=58), 0% and 14.2% in the renal dysplasia group (n=7), 0% and 26.1% in the non-CL-16 deficiency nephritis group (n=23), 8.9% and 46.7% in the hypogenesis syndrome group (n=45), 6.2% and 25.0% in the neonatal weak calf syndrome group (n=32), 9.1% and 38.6% in the respective dams group (n=44), 0% and 23.1% in the normal cattle group (n=13), and 5.9% and 38.2% in total (n=222), respectively. These results showed that the carrier rate of F11 deficiency was high in Japanese Black cattle, and that the CL-16 deficiency, hypogenesis syndrome, neonatal weak calf syndrome, and dams groups had a large amount of recessive homozygous genotype than the other groups. No abnormal bleeding was observed clinically in the present study, and 4 of the recessive homozygous dams showed normal growth and parturition.

Original languageEnglish
Pages (from-to)1251-1255
Number of pages5
JournalJournal of Veterinary Medical Science
Issue number12
Publication statusPublished - Dec 2006
Externally publishedYes


  • Claudin-16 deficiency
  • Factor XI deficiency
  • Growth retardation
  • Hypogenesis
  • Japanese Black cattle

ASJC Scopus subject areas

  • General Veterinary


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