TY - JOUR
T1 - Cartilage-derived anti-tumor factor (CATF) inhibits the proliferation of endothelial cells in culture
AU - Takigawa, Masaharu
AU - Shirai, Eiji
AU - Enomoto, Motomi
AU - Hiraki, Yuji
AU - Fukuya, Michiko
AU - Suzuki, Fujio
AU - Shiio, Tsuyoshi
AU - Yugari, Yasumi
N1 - Funding Information:
This work was supported in part by Grants-in-aid from the Ministry of Education, Science and Culture (F.S.) and the Research Foundation for Cancer and Cardiovascular Diseases (M.T.). We wish to thank Mrs. Elizabeth Ichihara for assistance in the preparation of this manuscript.
PY - 1985/7
Y1 - 1985/7
N2 - Previous studies showed that a cartilage-derived anti-tumor factor (CATF), which was extracted from bovine cartilage with l M guanidine hydrochloride, inhibited the growth of solid sarcoma 180, but not the growth of ascites tumors of sarcoma 180 [Suzuki, F. et al. Jpn. J. Bone Metab., 2, 231-235 (1984)]. This study showed that CATF inhibited the proliferation and DNA synthesis of endothelial cells isolated from bovine pulmonary artery, but not the proliferations of sarcoma 180, L1210 and L cells. These results suggest that CATF has anti-angiogenic properties, thereby inhibiting the growth of solid tumors.
AB - Previous studies showed that a cartilage-derived anti-tumor factor (CATF), which was extracted from bovine cartilage with l M guanidine hydrochloride, inhibited the growth of solid sarcoma 180, but not the growth of ascites tumors of sarcoma 180 [Suzuki, F. et al. Jpn. J. Bone Metab., 2, 231-235 (1984)]. This study showed that CATF inhibited the proliferation and DNA synthesis of endothelial cells isolated from bovine pulmonary artery, but not the proliferations of sarcoma 180, L1210 and L cells. These results suggest that CATF has anti-angiogenic properties, thereby inhibiting the growth of solid tumors.
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U2 - 10.1016/0309-1651(85)90054-2
DO - 10.1016/0309-1651(85)90054-2
M3 - Article
C2 - 4028190
AN - SCOPUS:84886639470
SN - 1065-6995
VL - 9
SP - 619
EP - 625
JO - Cell Biology International Reports
JF - Cell Biology International Reports
IS - 7
ER -