Case report: Timed IVM followed by ICSI in a patient with immature ovarian oocytes

Junko Otsuki, Yoshie Momma, Keiko Takahashi, Sachie Miyakura, Yasushi Nagai

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


A complete failure of meiotic maturation occasionally occurs following human chorionic gonadotrophin administration during IVF-intracytoplasmic sperm injection (ICSI) cycles. ICSI on day 1 is commonly used to allow maturation in culture. However, if the oocytes become mature in the evening soon after their recovery but ICSI is delayed until the next day, then subsequent ageing of matured oocytes may be unfavourable for fertilization and development. To avoid the deterioration associated with oocyte ageing, the timing of polar body extrusion was checked every 3 h and rescue in-vitro maturation (IVM)-ICSI was performed shortly after the polar body extrusion was confirmed. This report describes a successful pregnancy and birth of a healthy baby in a patient who had no mature oocytes at the time of oocyte retrieval, and illustrates the value of extra monitoring for IVM and ICSI in cases where only immature oocytes are available.

Original languageEnglish
Article number2158
Pages (from-to)101-103
Number of pages3
JournalReproductive BioMedicine Online
Issue number1
Publication statusPublished - Jul 2006
Externally publishedYes


  • ICSI
  • IVM
  • Meiotic maturation
  • Polar body extrusion

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology
  • Developmental Biology


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